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Genetic Immunization - Adrian Bot

Hardcover Published: 30th November 2000
ISBN: 9780306462269
Number Of Pages: 180

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Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

Approaches for Development of New Vaccinesp. 1
Genetic Vaccination: Routes and Formulationsp. 11
Intrinsic Adjuvant Properties of Plasmid DNAp. 25
Cellular Mechanisms Involved in the Immune Response Elicited by Genetic Immunizationp. 35
Protective Immune Responses Elicited by Genetic Immunization against Virusesp. 51
Immune Responses Elicited by Genetic Immunization with Bacterial, Fungal, or Parasitic Antigensp. 85
Autoimmunity, Allergy, and Genetic Vaccinesp. 99
Genetic Immunization against Tumorsp. 109
Genetic Vaccination of Neonatesp. 121
Indexp. 175
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306462269
ISBN-10: 0306462265
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 180
Published: 30th November 2000
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 24.77 x 16.51  x 1.91
Weight (kg): 0.59