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Genetic factors in coronary heart disease : Developments in Cardiovascular Medicine - Uri Goldbourt

Genetic factors in coronary heart disease

Developments in Cardiovascular Medicine

By: Uri Goldbourt (Editor), U. de Faire (Editor), K. Berg (Editor)

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Published: 30th September 1994
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Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors.
This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed.
Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.

List of Contributors
Introduction
Differences in frequency of atherosclerosis and coronary heart disease between populations and ethnic groupsp. 3
Variation of atherosclerosis and coronary heart disease by age and sexp. 21
Familial clustering of coronary heart disease: a review of its significance and role as a risk factor for the diseasep. 37
Studies of twins and adoptees in coronary heart diseasep. 55
Assessing genetic and cultural heritabilitiesp. 71
Lipids, apolipoproteins and lipoproteinsp. 83
Low density lipoprotein subclass phenotypesp. 105
Rabbit models in genetic research in atherosclerosisp. 115
Fibrinogen, factor VII, and plasminogen activator inhibitor-1p. 125
Homocysteinep. 139
Blood pressure variationp. 153
Rat models for atherosclerosisp. 179
Human obesitiesp. 189
Diabetes and insulin resistancep. 203
Smoking and sports participationp. 217
Genetic defects in lipoprotein metabolismp. 239
Familial hypercholesterolaemiap. 267
Lp(a) lipoprotein: a monogenic risk factor for cardiovascular diseasep. 275
Apolipoprotein E polymorphism and atherosclerosis riskp. 289
From random genetic markers to candidate genes in association and linkage studies of coronary heart disease and its risk factorsp. 301
Plasma triglyceride transportp. 309
Normal polymorphism at the low density lipoprotein receptor (LDLR) locus: effect on cholesterol levels and interaction with apolipoprotein E (apoE) genesp. 323
Intimal thickening, morphology and epidemiologyp. 331
Regulation of arterial smooth muscle cell proliferation during development and lesion formationp. 337
Reverse cholesterol transportp. 351
Gene-environment interaction: variability gene conceptp. 373
Genetic factors, cardiovascular reactivity and blood pressure variabilityp. 385
Genetic variation and nutritionp. 397
Genetic variation and cardiac pharmacotherapyp. 409
Practical approaches for finding and helping coronary-prone families with special reference to familial hypercholesterolaemiap. 425
Concluding remarksp. 447
Indexp. 449
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792327523
ISBN-10: 0792327527
Series: Developments in Cardiovascular Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 463
Published: 30th September 1994
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.88  x 3.18
Weight (kg): 0.85