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Genes, Oncogenes, and Hormones : Advances in Cellular and Molecular Biology of Breast Cancer - Robert B. Dickson

Genes, Oncogenes, and Hormones

Advances in Cellular and Molecular Biology of Breast Cancer

By: Robert B. Dickson (Editor), Marc E. Lippman (Editor)

Hardcover Published: 31st October 1992
ISBN: 9780792317487
Number Of Pages: 446

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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diĀ­ agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Foreword to the Series
Preface
Contributing Authors
The Progression of Node-Negative to -Positive Breast Cancerp. 1
Prognostic Factors in Axillary Node-Negative Breast Cancerp. 2
Role of Type IV Collagenases in Human Breast Cancerp. 21
Suppressor Genes and Negative Growth Factorsp. 43
Suppressor Genes in Breast Cancer: An Overviewp. 45
The Role of the Retinoblastoma Gene in Breast Cancer Developmentp. 59
Mammary Derived Growth Inhibitor (MDGI)p. 69
Roles for Transforming Growth Factors-[beta] in the Genesis, Prevention, and Treatment of Breast Cancerp. 97
Oncogenes and Stimulatory Growth Factorsp. 137
Mechanisms Involving an Expanding erbB/EGF Receptor Family of Tyrosine Kinases in Human Neoplasiap. 139
c-erbB[subscript 2] Amplification and Overexpression in Human Tumorsp. 161
Clinical Significance of c-erbB[subscript 2] Protein Overexpressionp. 181
Anti-p185HER2 Monoclonal Antibodies: Biological Properties and Potential for Immunotherapyp. 193
A Chimeric EGFR/neu Receptor in Studies of neu Functionp. 213
Involvement of Protein Kinase C in the Growth Regulation of Human Breast Cancer Cellsp. 229
Tyrosine Kinase Receptor - Nuclear Protooncogene Interactions in Breast Cancerp. 249
Steroid Hormone Receptorsp. 275
Characterization and Regulation of Estrogen and Progesterone Receptors in Breast Cancerp. 277
Estrogen and Progesterone Receptor Structure and Action in Breast Cancer Cellsp. 301
Progesterone Receptors in Breast Cancerp. 317
Differentiation and Function of Epithelium and Stroma in the Breastp. 353
Intermediate Filament Protein Expression in Normal and Malignant Human Mammary Epithelial Cellsp. 355
Casein Gene Expression: From Transfection to Transgenicsp. 379
The Whey Acidic Proteinp. 399
Stromal-Epithelial Interactions in Breast Cancerp. 413
Indexp. 433
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792317487
ISBN-10: 0792317483
Series: Topics in Molecular Organization and Engineering
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 446
Published: 31st October 1992
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 24.18 x 16.31  x 3.07
Weight (kg): 0.87