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Gene Therapy in Inflammatory Diseases : Progress in Inflammation Research - Christopher H. Evans

Gene Therapy in Inflammatory Diseases

Progress in Inflammation Research

By: Christopher H. Evans (Editor), Paul D. Robbins (Editor), M. J. Parnham (Editor)

Hardcover Published: March 2000
ISBN: 9783764358556
Number Of Pages: 260

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Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren's syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

List of contributors
Preface
Gene therapy for inflammatory diseases - basic conceptsp. 1
Gene therapy for rheumatoid arthritis: preclinical studiesp. 13
Cartilage erosion in rheumatoid arthritis: studies in SCID mouse modelp. 35
Gene therapy for rheumatoid arthritis: clinical studiesp. 53
Cytokine gene therapy of allergic airways inflammationp. 65
Gene therapy for inflammatory diseases of the salivary glandsp. 83
Gene therapy for management of lupus: correction of Fas and Fas ligand-induced apoptosis in murine disease - therapeutic rationale and strategiesp. 95
Gene therapy for multiple sclerosisp. 119
Gene therapy for type I diabetes mellitusp. 133
Gene transfer to facilitate transplantationp. 163
DNA vaccination as an anti-inflammatory strategyp. 205
Naked DNA as a gene delivery vehicle in inflammatory diseasesp. 231
Animal models of arthritis generated by gene transferp. 241
Indexp. 256
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764358556
ISBN-10: 3764358556
Series: Progress in Inflammation Research
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 260
Published: March 2000
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 1.75
Weight (kg): 0.56

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