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Gene Therapy for Autoimmune and Inflammatory Diseases : Milestones in Drug Therapy - Yuti Chernajovsky

Gene Therapy for Autoimmune and Inflammatory Diseases

Milestones in Drug Therapy

By: Yuti Chernajovsky (Editor), Paul D. Robbins (Editor)

Hardcover

Published: 29th May 2010
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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Kluber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

From the reviews: "This monograph contains new and valuable information regarding relevant topics ranging from disease entities to vectors and engineered cells. The authors, all of them international experts, take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long term genetic interventions. ... The present volume is of an exceptional value for clinicians and scientists interested in introducing gene therapy into clinical use." (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

List of Contributorsp. vii
Prefacep. xi
Gene therapy for arthritisp. 1
Gene therapy for the treatment of inflammatory bowel diseasep. 19
Gene therapy for diabetesp. 39
Gene therapy for cystic fibrosis lung diseasep. 47
Gene therapy of multiple sclerosisp. 65
Gene therapy for myositisp. 79
Gene therapy for osteoarthritisp. 91
Gene therapy: Sjögren's syndromep. 113
Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus diseasep. 127
Regulated promotersp. 147
Development of AAV vectors for the therapy of autoimmune and inflammatory diseasesp. 161
Delivery and application of plasmid DNA in arthritis gene therapyp. 181
Helper-dependent adenoviral vectorsp. 193
Cells as carriers of gene therapyp. 209
Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapyp. 223
Indexp. 233
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9783034601641
ISBN-10: 3034601646
Series: Milestones in Drug Therapy
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 239
Published: 29th May 2010
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 16.5  x 1.91
Weight (kg): 0.73