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Gene Genealogies, Variation and Evolution : A Primer In Coalescent Theory - Jotun Hein

Gene Genealogies, Variation and Evolution

A Primer In Coalescent Theory

Paperback Published: 1st December 2004
ISBN: 9780198529965
Number Of Pages: 296

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Coalescent theory tells us what gene genealogies are expected to look like if populations have different demographic histories - i.e, population size, structure, etc. The aim of this book is to provide an accessible introduction to Coalescent Theory with a view towards data analysis. Coalescent Theory has in the last two decades moved from being an obscure technique that appealed to mathematical population geneticists to a central tool in data analysis of DNA sequences. The completion of the sequencing of the human genome and accompanying determination of SNPs and haplotypes will increase its importance even further. This textbook, rich in examples and illustrations, is suitable for a graduate course in statistics, population-, molecular-, and medical genetics.

`The book succeeds very well in engendering enthusiasm for developing mathematical models and methods which can be applied to DNA sequence data, and it introduces the reader to open research problems.' Mathematical Reviews

Preface The basic coalescent From genealogies to sequences Trees and topologies Extensions to the basic coalescent The coalescent with recombination Getting parameters from data LD Mapping and the coalescent Human evolution Appendix: Web based tools

ISBN: 9780198529965
ISBN-10: 0198529961
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 296
Published: 1st December 2004
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 24.5 x 17.2  x 1.5
Weight (kg): 0.6