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Gastrointestinal Inflammation and Disturbed Gut Function : The Challenge of New Concepts - G. Holtmann

Gastrointestinal Inflammation and Disturbed Gut Function

The Challenge of New Concepts

By: G. Holtmann (Editor), Professor Nicholas J. Talley (Editor)

Hardcover Published: 30th September 2003
ISBN: 9780792387831
Number Of Pages: 290

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In gastrointestinal (GI) practice, a large proportion of patients present with what are currently classified as functional GI complaints. For decades, psychological causes have been implicated in the initiation and maintenance of symptoms. In recent years, disturbances of GI function including sensory motor abnormalities have been catalogued and are now believed to play a key role in the development of symptoms. A genetic predisposition may be important. Furthermore, evidence has accumulated that GI inflammation can trigger and maintains functional disturbances. In particular, acute GI inflammation appears to play a crucial role in at least a subgroup of patients. These observations potentially have profound implications for the field, and suggest that functional GI disorders are indeed organic diseases.

This book, the proceedings of Falk Symposium 130 on 'Gastrointestinal Inflammation and Disturbed Gut Function: The Challenge of New Concepts', held in Freiburg, Germany, on October 4-6, 2002 (Part I of the Gastroenterology Week Freiburg 2002), reviews ground-breaking work and will stimulate new research in the functional GI disorders, from the bench to the bedside. Basic scientists, clinical researchers and clinicians interested in this field explore controversial and exciting areas of research, and consider targets for future therapeutic interventions.

List of principal contributorsp. ix
Prefacep. xii
Setting the Scene: Epidemiology
Epidemiology of functional bowel disease and inflammatory bowel disease: a common link?p. 3
Extraintestinal manifestations and psychiatric illness in irritable bowel syndrome: is there a link?p. 10
Evidence of bidirectional cross-sensitization of the distal colon and lower urinary tract: a possible aetiology of concurrent irritable bowel syndrome and interstitial cystitisp. 17
Are dissociative mental disturbances responsible for visceral hyperalgesia in patients with functional abdominal pain?p. 29
Basic Mechanisms of Gastrointestinal Inflammation
Current knowledge regarding the initiation and regulation of gastrointestinal inflammation in inflammatory bowel diseasep. 35
Is the normal gut inflamed? And does it matter?p. 44
Disturbed Function in Inflammatory Bowel Disease
Symptomatic inflammatory bowel disease in remission--it could be irritable bowel syndromep. 53
The symptomatic IBD patient in remission--a manifestation of IBS?--Consp. 57
Herbal preparation in functional dyspepsia--Helicobacter pylori status is not a predictor for treatment success: results of a double-blind, randomized, placebo-controlled, multicentre trialp. 62
Intestinal gas dynamics and tolerance are modified by the different components of nutrientsp. 70
Inflammation and Nerve Function
Vagal afferents and regulation of inflammation and hyperalgesia in remote body domainsp. 79
Inflammation-induced changes in nerves as a basis for symptom generation in irritable bowel syndromep. 104
Inflammation-induced altered nerve function in the gut-does it play a role in gastrointestinal symptom generation?p. 109
Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammationp. 120
Regulation of vagal afferent sensitivity to gastric acidp. 126
Alterations of the enteric nervous system and interstitial cells of Cajal in functional colorectal motility disordersp. 136
Nerve Function Modulating Gut Inflammation
Sensory nerve function in gut inflammationp. 151
Neuroimmunology and the gastrointestinal tractp. 160
What Function is Disturbed in Functional Gastrointestinal Disorders and Why?
Visceral hypersensitivity in functional gastrointestinal disordersp. 169
Motor function and dysfunction in functional dyspepsia and irritable bowel syndromep. 176
A rational approach to Helicobacter pylori eradication in patients with functional dyspepsiap. 187
Con: Helicobacter pylori eradication--a rational approach for the treatment of patients with functional dyspepsia?p. 196
Animal Models on the Role of Inflammation in Gastrointestinal Function
Animal models for visceral sensitivityp. 205
Descending modulation of visceral hyperalgesiap. 213
Role of Acute Bacterial Infections in Irritable Bowel Syndrome
Epidemiology and clinical impact of post-infectious irritable bowel syndromep. 223
Potential mechanisms and therapeutic implications of bacterial infection in irritable bowel syndromep. 229
Role of epithelium--environment interactions in down-regulation of mucosal inflammationp. 239
Genetics and Molecular Mechanisms
Is irritable bowel syndrome a genetic disorder?p. 245
Localization and functions of neurokinin and N-methyl-D-aspartate receptorsp. 253
Replacing physiological variability by genetic variability--from gene to functionp. 260
The Brain, the Gut and the Genes
Gut function and dysfunction in functional gastrointestinal disorders: a personal viewp. 269
Indexp. 277
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780792387831
ISBN-10: 079238783X
Series: Falk Symposium : Book 130
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 290
Published: 30th September 2003
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.34

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