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Galanin : Experientia Supplementum - Tomas Hokfelt


Experientia Supplementum

By: Tomas Hokfelt (Editor)

Hardcover Published: 29th September 2010
ISBN: 9783034602273
Number Of Pages: 286

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Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Galanin: A Multitalented Neuropeptidep. 1
Galanin, Galanin Receptors, and Drug Targetsp. 7
Galanin Acts as a Trophic Factor to the Central and Peripheral Nervous Systemsp. 25
Galanin and Spinal Pain Mechanisms: Past, Present, and Futurep. 39
Galanin Family of Peptides in Skin Functionp. 51
Galanin in Glia: Expression and Potential Roles in the CNSp. 61
Galanin and the Neuroendocrine Axesp. 71
Galanin and Consummatory Behavior: Special Relationship with Dietary Fat, Alcohol and Circulating Lipidsp. 87
Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galaninp. 113
Galanin Impairs Cognitive Abilities in Rodents: Relevance to Alzheimer's Diseasep. 133
Neuroprotective Role for Galanin in Alzheimer's Diseasep. 143
Galanin, Galanin Receptor Subtypes and Depression-Like Behaviourp. 163
Galanin and Epilepsyp. 183
Galanin and Addictionp. 195
Galanin Systems and Ischemia: Peptide and Receptor Plasticity in Neurons and Oligodendroglial Precursorsp. 209
The Galanin System in Cancerp. 223
Galanin Systems in Non-mammalian Vertebrates with Special Focus on Fishesp. 243
Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproductionp. 263
Indexp. 281
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9783034602273
ISBN-10: 3034602278
Series: Experientia Supplementum : Book 102
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 286
Published: 29th September 2010
Country of Publication: CH
Dimensions (cm): 23.37 x 15.49  x 2.03
Weight (kg): 0.54