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Fundamentals of Inflammation - Charles N. Serhan

Fundamentals of Inflammation

By: Charles N. Serhan (Editor), Peter A. Ward (Editor), Derek W. Gilroy (Editor), Samir S. Ayoub (Contribution by)

Hardcover Published: 31st May 2010
ISBN: 9780521887298
Number Of Pages: 473

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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. The purpose of this book is to provide an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, postdoctoral Fellows, medical scientists, and researchers from other disciplines who wish to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Industry Reviews

'... a comprehensive volume that brings together many important and contemporary aspects of inflammation. This book will serve as an excellent guide to the current understanding of how 'inflammation' contributes in such diverse ways to disease processes, and to the resolution of the same through natural processes or clinical treatment.' The Quarterly Review of Biology
"A comprehensive volume that brings together many important and contemporary aspects of inflammation. The book will serve as an excellent guide to the current understanding of how "inflammation" contributes in such diverse ways to disease processes, and to the resolution of the same through natural processes or clinical treatment." Andrew Mellor, Quarterly Review of Biology

Acute inflammation and chronic inflammation
Resolution of acute inflammation and wound healing
Links between innate and adaptive immunity
Individual Cell Types
Neutrophils I
Neutrophils II
Mast cells as sentinels of inflammation
Basophils
Eosinophils Sophie Fillon
Macrophages
Lymphocytes
Fibroblasts and stromal cells
Cell-cell interactions: PMN endothelial cells
Chemical Mediators
Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins
Cytokines and chemokines / IL-1 family in inflammation
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Leukocyte generation of reactive oxygen species
Cell adhesion molecules
Immunopharmacology
Mediators and mechanisms of inflammatory pain
Non-steroidal anti-inflammatory drugs
Cytokines and chemokines in inflammation cancer
Inflammatory Diseases/Histology
Lung
Neural inflammation, Alzheimer's disease and stroke
Rheumatoid arthritis/SLE
Gastrointestinal inflammation and ulceration: mediators of induction and resolution
Inflammatory skin diseases
Kidney glomerulonephritis and renal ischemia
Inflammation in cardiovascular diseases
Animal Models of Inflammation
Models of acute inflammation - air-pouch, peritonitis and ischemia-reperfusion
Experimental models of glomerulonephritis
Ischemia reperfusion injury and glomerulonephritis
Asthma
Arthritis
Ocular inflammation models
Atherosclerosis in experimental animal models
Oral inflammation and periodontitis
Pathogens and inflammation
Diabetes
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521887298
ISBN-10: 0521887291
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 473
Published: 31st May 2010
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 27.94 x 21.59  x 3.18
Weight (kg): 1.68

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