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Frontiers In Viral Hepatitis - Schinazi

Frontiers In Viral Hepatitis

Hardcover Published: 12th December 2003
ISBN: 9780444509864
Number Of Pages: 598

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"Frontiers in Viral Hepatitis" provides a compilation of the research from over 40 key opinion leaders in the field of Hepatitis. The book focuses on the latest advances in the search for new, more effective therapeutic options and related topics in viral hepatitis. These include regulatory issues, epidemiology, and emerging viruses; immunology and vaccines; viral hepatitis B and C infections in children; genetics pathology and viral diagnosis; cell systems and animal models; novel therapeutics for hepatitis B and C; resistance and therapeutic strategies in humans; and prevention and treatment options for hepatocellular carcinoma.


The breadth of information published in this volume provides insight into current prevention and treatment options. Recent advances in our understanding of the molecular biology, immunology and pathogenesis of hepatitis viruses have accelerated at a remarkable rate, offering a more comprehensive perspective on hepatitis.

"This book will be an excellent source of information not only for hepatologists or research workers in hepatology, but also for clinicians interested in the basic science or viral hepatitis and in understanding the 'deep' pathogenic aspects of hepatocellular carcinoma" - DIGESTIVE AND LIVER DISEASE (2005)

Prefacep. xi
Acknowledgmentsp. xiv
Biographiesp. xv
Contributorsp. xix
Regulatory Issues, Epidemiology, and Emerging Virusesp. 1
Current issues in the regulation and approval of antiviral drugs for hepatitisp. 3
Molecular and serum epidemiology of HBV and HCV infection and the impact of antiviral agents in Chinap. 15
New viruses and their relationship to hepatitisp. 35
Immunology and Vaccinesp. 47
Virus-specific CD8+ cell immune responses in acute and chronic hepatitis B virus infectionp. 49
Cell-mediated immunity and the outcome of HCV infection in chimpanzeesp. 59
Adoptive immune transfer as a therapeutic approach for persistent hepatitis B virus infectionp. 71
Perspectives in HCV vaccine developmentp. 77
Viral Hepatitis B and C Infections in Childrenp. 87
Maternal/fetal/pediatric HBV and HCV infectionsp. 89
Effects of interferon treatment in children with post-transfusional chronic hepatitis Bp. 97
Genetics, Pathology and Viral Diagnosisp. 107
Effects of genotypic variations on hepatitis C virus nonstructural protein 5B structure and activityp. 109
Compartmentalization of hepatitis C viral quasispeciesp. 123
In situ localization of PCR-amplified hepatitis C virus RNA on human erythrocytesp. 131
Nucleic acid-based antiviral approaches to HBVp. 139
In vitro phenotype of HBV variants in patients with fulminant hepatitis Bp. 157
Evaluation of three commercially available HBV viral load assays: dynamic range, precision, and clinical utilityp. 165
Cell Systems and Animal Modelsp. 173
Cell lines that allow regulated expression of HCV proteins: principles and applicationsp. 175
Novel hepatitis C virus-positive cell line derived from a chimpanzee with chronic HCV infectionp. 187
A transgenic mouse lineage useful for testing antivirals targeting hepatitis B virusp. 197
Evaluation of therapies for hepatitis B virus in the HBV transgenic SCID mouse modelp. 211
Drug Discovery and Development: Novel Therapeutics for Hepatitis B and Cp. 223
Novel approaches in the management of chronic HBV infectionp. 225
Antiviral [beta]-L-nucleosides specific for hepatitis B virus infectionp. 245
Toxicological study of the anti-HBV agent [beta]-L-thymidinep. 263
Pharmacokinetics of [beta]-L-thymidine and [beta]-L-2'-deoxycytidine in woodchucks and monkeysp. 271
Clevudine: A novel 1-[beta]-L nucleoside analogue in clinical development for the treatment of HBV infectionp. 281
Glucosidase/protein folding inhibitors as possible mutation-proof, anti-hepatitis B & C agentsp. 301
Nuclease resistant ribozymes directed against hepatitis C virus RNA plus and minus strand inhibit viral replication of a HCV/poliovirus chimerap. 315
Mechanism of laser therapy of viral hepatitisp. 325
Drug Discovery and Development: Resistance and Therapeutic Strategies in Humansp. 333
Nomenclature for antiviral resistant human hepatitis B virus mutations in the polymerase regionp. 335
Complex genotypic changes during failure of HBV nucleoside analogue therapyp. 353
Lamivudine for chronic hepatitis B: Efficacy, safety, resistance, and current treatment issuesp. 365
Clinical experience and follow-up with lamivudine in the Asian populationp. 383
Impaired response to 5 mU/day interferon treatment in African-Americans with chronic hepatitis Cp. 391
Novel combined approaches to hepatitis C therapiesp. 399
Consensus + pegylated interferonp. 413
Impact of interferon alpha-2b and of combination with ribavirin on progression of liver fibrosis in patients with chronic hepatitis Cp. 425
Decorin expression in chronic hepatitis C; effect of interferon alpha treatmentp. 441
Preclinical and clinical development of the anti-HIV, anti-HBV oxathiolane nucleoside analog emtricitabinep. 451
CD81 receptor expression in human cells: Implications for HCV therapeuticsp. 485
Prevention and Treatment Options for Hepatocellular Carcinomap. 493
Resolution of hepatic fibrosis as a consequence of interferon therapy for hepatitis Cp. 495
Symptomatic therapies for prevention of hepatocellular carcinoma developing in chronic hepatitis Cp. 515
Mutations of the core gene sequence of HCV from patients with hepatocellular carcinoma in Chinap. 531
Characterization of hepatitis B virus X variants that are integrated and expressed in human hepatocellular carcinomasp. 547
Subject indexp. 557
Author indexp. 567
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780444509864
ISBN-10: 0444509860
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 598
Published: 12th December 2003
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 24.5 x 16.9  x 2.8
Weight (kg): 1.22