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Frontiers in Clinical Neuroscience : Neurodegeneration and Neuroprotection A Symposium in Abel Lajtha's Honour - Laszlo Vecsei

Frontiers in Clinical Neuroscience

Neurodegeneration and Neuroprotection A Symposium in Abel Lajtha's Honour

By: Laszlo Vecsei (Editor)

Hardcover Published: 30th November 2003
ISBN: 9780306480386
Number Of Pages: 195

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Over the last decade, the considerable progress made in biochemistry, molecular biology, genetics and neuropharmacology has revealed some ofthe intimate mechanisms ofthe neurodegenerative disorders. There is increasing evidence linking genetic defects affecting mitochondria to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and some other neurological disorders. Advances in knowledge are fueled through improved animal models that use mitochondrial toxins, excitotoxins, and transgenic animals. Therapeutic studies in these models have strengthened the possibility for effective treatments in man. By defining the pathomechanisms, we hope to be in the position to prevent cell death by protecting neurons. Indeed serious preclinical and clinical research is going on in the field of neuroprotection in stroke, Parkinson's disease, epilepsy, demyelinating disorders and dementia. Based on these scientific ideas, the Symposium in honour of Professor Abel Lajtha was organized by the European Society for ClinicalNeuropharmacology(ESCNP) and the Danube Symposium for Neurological Sciences in Budapest, Hungary, October 24-25, 2002. Professor Lajtha was born in Budapest in 1922 and his home town is an ideal venue for strengthening the bonds between Western and Eastern European Neuroscientists. Professor Peter Riederer (Wurzburg) held the 2002 special "Dezso Miskolczy Memorial Lecture" in Abel Lajtha's Honour. Thanks are due to the invited speakersofthis Symposium for their excellentcontribution. Laszlo Vecsei vii CONTENTS Advances in Neuroprotection Research for Neurodegenerative Diseases 1 Mario E. Gotz and Peter Riederer Neurotransmitter Release in Experimental Stroke Models: The Role of Glutamate-GABA Interaction 21 Laszlo G. Harsing, Jr.

From the reviews: "The book gives a broad and simultaneously deep insight in different fields of neurodegeneration and neuroprotection. The chapters are clearly structured and comprehensive without being overloaded. Many clear tables and figures help to illustrate the important issues. ! it is very suitable for advanced students of the biomedical field, physicians as well as basic scientists. ! provides an excellent basis for database searches to get to the most recent results on selected topics." (Dr. Christoph B. Lucking, Journal of Neurology, Vol. 252 (11), 2005)

Advances in Neuroprotection Research for Neurodegenerative Diseasesp. 1
Neurotransmitter Release in Experimental Stroke Models: The Role of Glutamate-GABA Interactionp. 21
Neuroprotection in Ischemic/Hypoxic Disorders: From the Preclinical to the Clinical Testingp. 39
Neuroprotection and Dopamine Agonistsp. 55
COMT Inhibition in the Treatment of Parkinson's Disease: Neuroprotection and Future Perspectivesp. 75
Neuroprotection and Epilepsyp. 91
Neuroprotection and Glatiramer Acetate: The Possible Role in the Treatment of Multiple Sclerosisp. 111
Causes and Consequences of Disturbances of Cerebral Glucose Metabolism in Sporadic Alzheimer Disease: Therapeutic Implicationsp. 135
Neuroprotection: A Realistic Goal for Aged Brain?p. 153
Kynurenines in Neurodegenerative Disorders: Therapeutic Considerationp. 169
Indexp. 185
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780306480386
ISBN-10: 0306480387
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 195
Published: 30th November 2003
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.05