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From Basic Immunology to Immune-Mediated Demyelination : Topics in Neuroscience - Gianvito Martino

From Basic Immunology to Immune-Mediated Demyelination

Topics in Neuroscience

By: Gianvito Martino (Editor), Luciano Adorini (Editor)

Hardcover Published: 1st March 1999
ISBN: 9788847000544
Number Of Pages: 315

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Morphological, physiological and pathological evidence demonstrates that ner­ vous and immune systems interact not only in maintaining brain homeostasis, but also in causing neurological diseases. The studyofthese interactions repre­ sents the basis on which neuroimmunologyhas grown during the years. At pre­ sent, several neurological diseases are recognized to be caused by a derange­ ment of the immune system in either its regulatory or effector functions. The main scope ofthis book, to discuss how an unbalanced immune system maylead to immune-mediated neurological diseases, is achieved in three parts. The first part provides an overview on how the immune system works. This is propaedeutical to understanding interactions between the immune and ner­ vous systems, which are discussed in the second part. The third part of the book focuses on one particular area of neuroimmunology, the immune disor­ ders leading to the damage of central and peripheral myelin. Given the opportunity to review first the immune system in itself and then how it operates during immune-mediated demyelinating disorders, we have tried to provide the reader with a basis for clearly understanding how interac­ tions between the immune and nervous systems can be protective or pathoge­ nic. This knowledge is a prerequisite for a rationale immune intervention tar­ geting these disorders.

Protective versus harmful responses and immune regulation
Organization of the immune system antigen recongnition and autoimmunity Assembly and function of immunoglobulines during B cell development
Immunological tolerance Pathogenetic mechanisms of autoimmunity
Adhesion receptors involved in leukocyte functions The endothelium of the brain microvasculature and the organization of intercellular junction
Chemokine and chemokine receptors The1/Th2 cytokine network
Lymphocyte trafficking in the central nervous system
Antigen presentation in the central nervous system
Adhesion molecules and the blood-brain-barrier in multiple sclerosis
Myelination steps in the central nervous system
Genomic screen in multiple slerosis MHC and multiple sclerosis
Cytokine genes in multiple sclerosis Non-myelin antigen autoreactivity in multiple sclerosis
Myelin antigen autoreactivity in multiple sclerosis
Inflammation and demyelination
Magnetic resonance and blood-brain barrier dysfunction in multiple sclerosis
Immunotherapies for multiple sclerosis
Animal models of demyelination of the central nervous system MHC and non MHC genetics of rat EAE
Genetic of hereditary neuropathies Animal models of demyelination in the PNS Immune-mediated neuropathies: diagnostic procedures
Pathology of demyelination neuropathies
Immunopathogenetic role of anti-neural antibodes in demyelinating dysimmune neuropathies
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9788847000544
ISBN-10: 8847000548
Series: Topics in Neuroscience
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 315
Published: 1st March 1999
Publisher: SPRINGER VERLAG GMBH
Country of Publication: IT
Dimensions (cm): 23.39 x 15.6  x 1.91
Weight (kg): 0.64