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Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes of Biosensor Surfaces - Neeti Sadana

Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes of Biosensor Surfaces

Hardcover

Published: 1st January 2008
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Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface.
The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc.
As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company.
- Modelling of binding and dissociation kinetics of analyte-receptor reactions on biosensor surfaces: provides physical insights into these reactions occurring on biosensor surfaces. Very few researchers even attempt to analyze the kinetics of these types of reactions.
- Fractal analysis used to model the binding and dissociation kinetics: original and unique approach.
- Economic analysis provided in the last chapter: helps balance the book; besides providing much-needed information not available in the open literature.
- Emphasis on improving biosensor performance parameters: helps make biosensors better.
- Empahsis on medically-related analytes: helps in prognosis of diseases.

Prefacep. ix
Introductionp. 1
Cost and Implications of Medical Care of Some Common Diseasesp. 1
Modeling and Theoryp. 5
Introductionp. 5
Theoryp. 8
Variable rate coefficientp. 8
Single-fractal analysisp. 10
Dual-fractal analysisp. 12
Triple-fractal analysisp. 14
Pfeifer's fractal binding rate theoryp. 15
Biosensor Performance Parameters and their Enhancementp. 19
Introductionp. 19
Theoryp. 21
Single-fractal analysisp. 21
Dual-fractal analysisp. 22
Resultsp. 23
Conclusionsp. 51
Fractal Analysis of Harmful Bacteria, Toxins, and Pathogen Detection on Biosensor Surfacesp. 55
Introductionp. 55
Theoryp. 56
Single-fractal analysisp. 56
Dual-fractal analysisp. 57
Resultsp. 58
Conclusionsp. 86
Fractal Binding and Dissociation Kinetics of Disease-Related Compounds on Biosensor Surfacesp. 89
Introductionp. 89
Theoryp. 90
Single-fractal analysisp. 90
Dual-fractal analysisp. 91
Resultsp. 92
Conclusionsp. 118
Fractal Analysis of Binding and Dissociation of Analytes that Help Control Diseases on Biosensor Surfacesp. 123
Introductionp. 123
Theoryp. 124
Single-fractal analysisp. 124
Dual-fractal analysisp. 125
Resultsp. 126
Conclusionsp. 147
Fractal Analysis of Binding and Dissociation of Small Molecules Involved in Drug Discovery on Biosensor Surfacesp. 151
Introductionp. 151
Theoryp. 152
Single-fractal analysisp. 152
Dual-fractal analysisp. 153
Resultsp. 154
Conclusionsp. 181
Fractal Binding and Dissociation Kinetics of Prion-Related Interactions on Biosensor Surfacesp. 185
Introductionp. 185
Theoryp. 186
Single-fractal analysisp. 186
Dual-fractal analysisp. 187
Resultsp. 187
Conclusionsp. 196
Fractal Analysis of Binding and Dissociation of DNA-Analyte Interactions on Biosensor Surfacesp. 199
Introductionp. 199
Theoryp. 200
Single-fractal analysisp. 200
Dual-fractal analysisp. 201
Resultsp. 202
Conclusionsp. 225
Fractal Analysis of Binding and Dissociation of Protein-Analyte Interactions on Biosensor Surfacesp. 229
Introductionp. 229
Theoryp. 230
Single-fractal analysisp. 230
Dual-fractal analysisp. 231
Resultsp. 232
Conclusionsp. 255
Fractal Analysis of Different Compounds Binding and Dissociation Kinetics on Biosensor Surfacesp. 259
Introductionp. 259
Theoryp. 260
Single-fractal analysisp. 260
Dual-fractal analysisp. 261
Resultsp. 262
Conclusionsp. 292
Fractal Analysis of Binding and Dissociation Kinetics of Environmental Contaminants and Explosives on Biosensor Surfacesp. 297
Introductionp. 297
Theoryp. 298
Single-fractal analysisp. 298
Dual-fractal analysisp. 299
Resultsp. 299
Conclusionsp. 312
Market Size and Economics for Biosensorsp. 317
Introductionp. 317
Collaboration between Companies, Universities, and State and Governmental Agencies: Trends in Collaborationp. 320
Factors that Could Help Increase/Decrease Biosensor Marketsp. 322
Examples of Biosensor Companies, their Product, and their Financial Backersp. 324
Conclusionsp. 331
Indexp. 335
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780444530103
ISBN-10: 044453010X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 372
Published: 1st January 2008
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 24.0 x 16.5  x 2.21
Weight (kg): 0.82