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Febrile Seizures - Tallie Z. Baram

Hardcover

Published: 1st January 2002
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Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following:
* New imaging tools and emerging data, visualizing effects of febrile seizures on the brain
* New genetic methodologies
* The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure.
Key Features
* First book on febrile seizures in over 20 years
* Broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods
* Comprehensive update of the topic, written by world leaders in the field
* Novel and newly discovered information based on up-to the minute methods
* Engaging style, accessible to the clinician, researcher, and educated parent

"Primary care physicians, child neurologists, and basic scientists will find this book useful in their clinical practice and/or research...it provides new information in a very readable format...the editors and authors have done an excellent job of organizing and presenting the content of the book."- EPILEPSY & BEHAVIOR (July 2002) "...the first text devoted to febrile seizures published in the last 20 years...it will be useful to clinicians who want to update their knowledge of the basic research relevant to febrile seizures and current management strategies...for the researcher, the text will provide an excellent summary of the current state of the science and provides many potential questions for future research."-EPILEPSY RESEARCH (July 2002) "I highly recommend Febrile Seizures to clinical neurologists and neurology residents who would like to own a current, thorough reference book on febrile seizures. It also would be great background reading for junior researchers interested in pediatric epilepsies, mesial temporal sclerosis, or developmental vulnerability to neuronal injury." @source-Donald L. Gilbert for ANNALS OF NEUROLOGY (October 2002) "It will be useful to clinicians who want to update their knowledge of the basic research relevant to febrile seizures and current management strategies. For the researcher, the text will provide an excellent summary of the current state of the science and provides many potential questions for future research." -Elizabeth Donner, Harvard Medical School Children's Hospital for EPILEPSY RESEARCH (2002) "...a comprehensive and stimulating review of the state of the art by bringing together experts from many countries and disciplines. ...This is a book that will be a welcome addition to the library of every pediatric neurologist, every epileptologist, and every researcher working on experimantal models of epilepsy. ...It provides a platform for the wealth of diverse and fascinating information about febrile seizures and adds a crucial perspective to a vast array of data that will help new researchers to see the fascinating questions ahead and to avoid potential pitfalls." -Eileen P.G. Vining, Johns Hopkins School of Medicine for THE NEW ENGLAND JOURNAL OF MEDICINE (August 2002) "This is a wonderful book. The editors and contributors are to be congratulated for compiling such a useful monograph. ...the chapters are consistently well written. ...I would enthusiastically recommend this book to everyone who has interest in any aspect of febrile seizures." -Marvin A. Fishman, Texas Children's Hospital for PEDIATRIC NEUROLOGY (2002)

Contributorsp. xvii
Prefacep. xxi
Acknowledgmentsp. xxiii
Epidemiology of Febrile Seizures
The Incidence and Prevalence of Febrile Seizures
Introductionp. 1
What Is a Febrile Seizure?p. 2
Determining Febrile Seizure Incidence and Prevalencep. 7
How Common Are Febrile Seizures?p. 15
Why Do We Need Epidemiological Data?p. 20
Referencesp. 21
Antecedents and Risk Factors for Febrile Seizures
Introductionp. 27
Summary of Key Studiesp. 29
Synthesisp. 34
How Do We Make This Information Useful?p. 35
Referencesp. 35
Recurrent Febrile Seizures
Introductionp. 37
Risk of a Recurrent Febrile Seizurep. 38
Factors That Predict a First Recurrencep. 40
Complex Featuresp. 46
The Role of Treatment in Reducing Riskp. 47
Summaryp. 48
Referencesp. 49
Population Studies on the Outcome of Febrile Seizures
Cognitive Outcome of Febrile Seizures
Introductionp. 53
Animal Studiesp. 54
Human Studiesp. 54
Prolonged or Complex Febrile Seizuresp. 57
Behavioral Outcomesp. 58
Behavioral and Cognitive Side Effects Associated with Antiepileptic Drugsp. 59
Conclusionp. 59
Referencesp. 60
Febrile Seizures and the Risk for Epilepsy
Introductionp. 63
Risk for Unprovoked Seizures Following a First Febrile Seizurep. 65
Risk Factors for Unprovoked Seizures among Children with Febrile Seizuresp. 66
Febrile Seizures in Cohorts with Epilepsyp. 72
Do Antiepileptic Drugs Prevent Unprovoked Seizures Following Febrile Seizures?p. 74
Conclusionsp. 74
Referencesp. 74
Do Febrile Seizures Promote Temporal Lobe Epilepsy? Retrospective Studies
Studiesp. 78
Conclusionsp. 82
Referencesp. 83
Do Febrile Seizures Lead to Temporal Lobe Epilepsy? Prospective and Epidemiological Studies
Introductionp. 88
Prospective Epidemiological Studies of Febrile Seizuresp. 88
Prospective Randomized Therapeutic Trials of Febrile Seizuresp. 89
Prospective Studies of Febrile Status Epilepticusp. 90
Epidemiological Studies of Epilepsyp. 91
Limitations of Prospective and Population-Based Studiesp. 94
Febrile Seizures and Temporal Lobe Epilepsy: Causal Relationship or Early Marker for Subsequent Temporal Lobe Epilepsy?p. 96
Referencesp. 98
Do Prolonged Febrile Seizures Cause Acute Neuronal Injury?
Do Prolonged Febrile Seizures Injure the Hippocampus? Human MRI Studies
Introductionp. 103
Retrospective MRI Studies Examining the Link of Complex Febrile Seizures to Hippocampal Injuryp. 105
Prospective MRI Studies in Children with Prolonged Seizuresp. 108
MRI Studies and Potential Mechanisms of Hippocampal Injuryp. 113
Considerations in MRI Methodology for Detecting Hippocampal Injury Following Complex Febrile Seizuresp. 117
Summaryp. 121
Referencesp. 121
Do Prolonged Febrile Seizures Injure Hippocampal Neurons? Insights from Animal Models
Introductionp. 128
Do Prolonged Experimental Febrile Seizures Cause Acute Hippocampal Cell Death?p. 129
Do Experimental Febrile Seizures Induce Loss of Specific, Vulnerable Populations of Hippocampal Neurons?p. 130
Do Prolonged "Febrile Seizures" Alter Neurogenesis of the Dentate Gyrus Granule Cells?p. 132
Do Prolonged "Febrile" Seizures Injure Specific Populations of Hippocampal Neurons?p. 133
Conclusionp. 134
Referencesp. 135
Do Effects of Febrile Seizures Differ in Normal and Abnormal Brain?
Introductionp. 139
Effects of Febrile Seizures in the Normal Developing Ratp. 141
Effects of Febrile Seizures in the Abnormal Developing Ratp. 144
Referencesp. 148
The Neurobiology of Febrile Seizures and of Their Consequences: Experimental Approaches
Why Does the Developing Brain Demonstrate Heightened Susceptibility to Febrile and Other Provoked Seizures?
Introductionp. 153
The Clinical Problemp. 154
Conclusionp. 162
Referencesp. 162
Mechanisms of Fever and Febrile Seizures: Putative Role of the Interleukin-1 System
Introductionp. 169
The Febrile Responsep. 170
IL-1[beta] in Seizures and Epileptogenesisp. 178
Human Epileptic Tissuep. 182
Mechanisms of Action and Pharmacological Implicationsp. 183
Referencesp. 184
Animal Models for Febrile Seizures
Introduction: Why Use Animal Models to Study Febrile Seizures?p. 189
Characteristics of the Optimal Animal Model for Febrile Seizuresp. 190
Published Models of Febrile Seizuresp. 195
Animal Models: Strengths, Limitations, and Usesp. 197
Referencesp. 198
Physiology of Limbic Hyperexcitability after Experimental Complex Febrile Seizures: Interactions of Seizure-Induced Alterations at Multiple Levels of Neuronal Organization
Introductionp. 203
Limbic Excitability after Experimental Complex Febrile Seizuresp. 204
Conclusions and Outlookp. 210
Referencesp. 212
Do Prolonged Febrile Seizures in an Immature Rat Model Cause Epilepsy?
Do Human Data Support the Notion That Prolonged Febrile Seizures Cause Epilepsy?p. 216
Use of Experimental Complex Febrile Seizures to Address Their Relationship to Epileptogenesisp. 217
Consequences of Prolonged Experimental Febrile Seizuresp. 218
Consequences of Experimental Prolonged Febrile Seizures in This Modelp. 222
Functional Consequences of Febrile Seizuresp. 225
Mechanisms for the Enhanced Excitability after Prolonged Experimental Febrile Seizuresp. 226
Summaryp. 227
Referencesp. 227
Basic Electrophysiology of Febrile Seizures
Introductionp. 232
Neuronal Processes Sensitive to Temperaturep. 233
Whole-Animal Studies of Hyperthermiap. 242
Conclusionp. 243
Referencesp. 244
Genetics of Febrile Seizures
The Genetics of Febrile Seizures
Introductionp. 249
Population, Family, and Twin Studies of Febrile Seizuresp. 250
Genetic Analysis Methodsp. 254
Known Linkages for Febrile Seizuresp. 258
Summaryp. 261
Referencesp. 262
Current Management of Febrile Seizures
Evaluation of the Child with Febrile Seizures
Introductionp. 266
Diagnostic Evaluationp. 266
Should the Child with a Febrile Seizure Have a Lumbar Puncture?p. 268
Electroencephalography in the Management of Febrile Seizuresp. 270
Referencesp. 271
Practical Management Approaches to Simple and Complex Febrile Seizures
Introductionp. 274
Continuous Prophylaxisp. 276
Intermittent Prophylaxisp. 279
Immediate Anticonvulsant Therapyp. 287
Antipyretic Treatmentp. 291
Deciding Who and How to Treatp. 292
Supportive Family Managementp. 296
Referencesp. 296
What Do We Tell Parents of a Child with Simple or Complex Febrile Seizures?
Introductionp. 305
Informationp. 306
Learning Theoriesp. 313
Conclusionsp. 313
Available Resourcesp. 314
Referencesp. 315
Current State of the Art: Implications for Future Study and Treatment
Human Data: What Do We Know about Febrile Seizures and What Further Information Is Needed
Geneticsp. 317
Role of Magnetic Resonance Imaging and Functional Imaging in Defining Seizure-Induced Hippocampal Injuryp. 318
Role of Preexisting Abnormalities in Seizure-Induced Injuryp. 319
Fever versus Hyperthermiap. 319
Role of Specific Pathogensp. 320
Epilepsy Syndromesp. 320
The Controversial Relationship between Prolonged Febrile Seizures, Mesial Temporal Sclerosis, and Temporal Lobe Epilepsyp. 321
Cognitive and Behavioral Outcomes and Memoryp. 321
Treatment and Neuroprotectionp. 322
Summaryp. 323
Referencesp. 323
Mechanisms and Outcome of Febrile Seizures: What Have We Learned from Basic Science Approaches, and What Needs Studying?
What Are the Key Questions?p. 325
What Have We Learned So Far?p. 327
What Are the Goals for Experimental Approaches to Febrile Seizures?p. 327
Referencesp. 328
Indexp. 329
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780120781416
ISBN-10: 0120781417
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 337
Published: 1st January 2002
Publisher: ACADEMIC PR INC
Country of Publication: US
Dimensions (cm): 22.91 x 15.19  x 2.06
Weight (kg): 0.65