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Fatty Liver Disease : NASH and Related Disorders - Jacob George

Fatty Liver Disease

NASH and Related Disorders

By: Jacob George (Editor), Pauline de la M. Hall (Editor), Arthur J. McCullough (Editor), Geoffrey C. Farrell (Editor)


Published: 10th December 2004
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Fatty liver disease, especially non-alcoholic steatohepatitis (NASH), is emerging as the most common form of liver disease - affecting at least 5% of the population of western countries with increasing incidence in developing economies in other continents (particularly Asia, Australia, South America and South Africa). NASH is the form of fatty liver disorder which can result in cirrhosis, particularly in those with diabetes or who are overweight, yet it is still not widely recognised as the most common form of liver disease. This book explains what NASH is, why it happens, who gets it, how it can result in cirrhosis, when to think about it, how to select practical management between those with a minor abnormality from those who may have cirrhosis, and how to prevent and treat this ubiquitous condition. Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It should appeal to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. There is a dearth of assembled information about NASH: such information is sought by physicians of various backgrounds, and detailed information is required by gastroenterologist, hepatologists, general physicians, diabetologists, nutritionalists and pathologists. Information on the diagnosis, management and understanding of this disease is only available in recent reviews - it is not covered in standard texts and there is no specific book available on the subject so far. The reader will benefit from the book by improving their diagnostic acumen for people with abnormal liver tests, improving knowledge about an important subject that will assist them in specialist or undergraduate exams, and will improve management of a common disorder.

"A superb updated review of a topic of dramatically increasing importance, written by leading authorities in the field. The book is well organised and balanced with excellent homogeneity" "A comprehensive book of invaluable help in diagnosing and managing NAFLD/NASH. Again, an outstanding source of current data concerning this epidemiologically important problem" Digestive and Liver Disease "Fatty Liver Disease is a state--of--the--art textbook coauthored by a number of top--notch experts and should be viewed as an invaluable contribution to the proper management of fatty liver diseases and all its coexisting conditions." New England Journal of Medicine, 353;20 November 2005



1 Overview: an introduction to NASH and related fatty liver disorders.

2 Pathology of hepatic steatosis, NASH and related conditions.

3 The epidemiology and risk factors of NASH.

4 Insulin resistance in NAFLD: potential mechanisms and therapies.

5 NASH as part of the metabolic (insulin resistance) syndrome.

6 NASH is a genetically determined disease.

7 The pathogenesis of NASH: human studies.

8 Animal models of steatohepatitis.

9 Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH.

10 Cytokines and inflammatory recruitment in NASH: experimental and human studies.

11 Mitochondrial injury and NASH.

12 Cell biology of NASH: fibrosis and cell proliferation.

13 Clinical manifestations and diagnosis of NAFLD.

14 The clinical outcome of NAFLD including cryptogenic cirrhosis.

15 Practical approach to the diagnosis and management of people with fatty liver diseases.

16 Management of NASH: current and future perspectives on treatment.

17 NAFLD, NASH and orthotopic liver transplantation.

18 NAFLD/NASH is not just a ?Western? problem: some perspectives on NAFLD/NASH from the East.

19 NAFLD/NASH in children.

20 Steatohepatitis resulting from intestinal bypass.

21 Specific disorders associated with NAFLD.

22 Hepatocellular carcinoma in NAFLD.

23 Does NASH or NAFLD contribute to comorbidity of other liver diseases?.

24 Recent advances.


ISBN: 9781405112925
ISBN-10: 1405112921
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 336
Published: 10th December 2004
Publisher: John Wiley and Sons Ltd
Country of Publication: GB
Dimensions (cm): 26.5 x 18.8  x 2.4
Weight (kg): 0.81
Edition Number: 1