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Familial Breast and Ovarian Cancer : Genetics, Screening and Management - Patrick J. Morrison

Familial Breast and Ovarian Cancer

Genetics, Screening and Management

By: Patrick J. Morrison (Editor), Shirley V. Hodgson (Editor), Neva E. Haites (Editor)

Hardcover Published: 9th December 2002
ISBN: 9780521803731
Number Of Pages: 418

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This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. This area has advanced in knowledge so rapidly that this publication provides an unrivalled source of information including sections on ethical and insurance issues and the different cultural differences in breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are detailed. The volume will be of immense value to all clinical geneticists, oncologists, and healthcare professionals involved in screening and counselling programmes.

'... this is a very good state of the art document of the current knowledge, covering most aspects of the genetic background and the clinical management of suspected familial breast and ovarian cancer in mid-2002 ... for those in the phase of starting up a clinical service the book contains valuable information and would be very useful as a basic guide...'. Human Genetics 'Colleagues throughout the profession from a wide range of disciplines will find much in this book to interest them and will help them guide and manage their patients through the difficult decision journey of familial cancer.' The Ulster Medical Journal ' ... members of the cancer genetics team who found it immediately useful ... the usefulness of the text is such that I found myself reading it from cover to cover. No chapter is weak ... I recommend it to all clinical geneticists working in cancer genetics, to breast surgeons and gynaecologists who deal with these cancers, and to radiologists involved in screening programmes. It provides an excellent review of the state of the art, with all the relevant references. Journal of the Royal Society of Medicine

List of contributorsp. ix
Forewordp. xiii
Prefacep. xv
Molecular biology and natural historyp. 1
Introductionp. 3
Overview of the clinical genetics of breast cancerp. 6
Cowden syndrome and related disordersp. 22
Overview of the clinical genetics of ovarian cancerp. 43
Ovarian and breast cancer as part of hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary colorectal cancer syndromesp. 73
The natural history of hereditary breast cancerp. 81
Pathology of the breast and ovary in mutation carriersp. 108
Risk estimation for familial breast and ovarian cancerp. 125
Screeningp. 141
Developing a cancer genetics service: a Welsh modelp. 143
Referral criteria for cancer genetics clinicsp. 157
Guidelines for the development of cancer genetics servicesp. 166
Cultural and educational aspects influencing the development of cancer genetics services in different European countriesp. 194
Screening, detection and survival patterns of breast and other cancers in high-risk familiesp. 204
Screening for familial ovarian cancerp. 220
Managementp. 235
Management of BRCA1/2 mutation carriersp. 237
Management of familial ovarian cancerp. 275
Prophylactic mastectomy in mutation carriersp. 286
Psychosocial aspects of genetic counselling for breast and ovarian cancerp. 295
BRCA1/2 testing: uptake and its measurementp. 306
Breast cancer genetics: ethical, social and insurance issuesp. 339
Gene therapy for breast and ovarian cancerp. 372
Future directionsp. 384
Indexp. 393
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780521803731
ISBN-10: 052180373X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 418
Published: 9th December 2002
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 25.15 x 17.78  x 2.54
Weight (kg): 1.04