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Experimental Mass Spectrometry : Selected Topics in Mass Spectrometry - David H. Russell

Experimental Mass Spectrometry

Selected Topics in Mass Spectrometry

By: David H. Russell (Editor)

Hardcover

Published: 30th April 1994
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Mass spectrometry underwent dramatic changes during the decade of the 1980s. Fast atom bombardment (F AB) ionization, developed by Barber and coworkers, made it possible for all mass spectrometry laboratories to analyze polar, highly functionalized organic molecules, and in some cases ionic, inorganic, and organometallic compounds. The emphasis of much of this work was on molecular weight determination. Parallel with the development of ionization methods (molecular weight mass spectrometry) for polar biological molecules, the increased mass range of sector and quadrupole mass spectrometers and the development of new instruments for tandem mass spectrometry fostered a new era in structural mass spectrometry. It was during this same period that new instrument technologies, such as Fourier transform ion cyclotron resonance, radio- frequency quadrupole ion trap, and new types of time-of-flight mass spectrometers, began to emerge as useful analytical instruments. In addi- tion, laser methods useful for both sample ionization and activation became commonplace in almost every analytical mass spectrometry laboratory. In the last 5 years, there has been explosive growth in the area of biological mass spectrometry. Such ionization methods as electrospray and matrix-assisted laser desorption ionization (MALDI) have opened new frontiers for both molecular weight and structural mass spectrometry, with mass spectrometry being used for analysis at the picomole and even femto- mole levels. In ideal cases, subfemtomole sample levels can be successfully analyzed. Sample-handling methods are now the limiting factor in analyz- ing trace amounts of biological samples.

The fragmentations of (M-H)[superscript -] Ions Derived from Organic Compounds: An Aid to Structure Determination
Gas-Phase Chemistry of Alkali Adducts of Simple and Complex Molecules
Fundamental Studies of Collision-Induced Dissociation of Ions
Multiple Pulses and Dimensions in FTICR
Experimental Fourier Transform Ion Cyclotron Resonance Mass Spectroscopy
Elucidation of Protein Structure and Processing Using Time-of-Flight Mass Spectrometry
Electrospray Ionization Mass Spectrometry and Tandem Mass Spectrometry of Large Biomolecules
Liquid Chromatography/Fast Atom Bombardment Mass Spectrometry
Index
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306444579
ISBN-10: 0306444577
Series: Selected Topics in Mass Spectrometry
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 311
Published: 30th April 1994
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.42