Excited states and free radicals are involved in the normal physiology of living systems, in pathological processes (including lipid peroxidation, inflammation, Parkinson's disease, cancer, and aging), in the mechanisms of drug action, and in the photochemotherapies such as the PUVA therapy for skin diseases and PDT for cancer. This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine. The authors explore in particular how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems. Topics include the nature of excited states and free radicals and the techniques for their study, activated oxygen species, DNA, proteins, carotenoids and photosynthetic reaction centers, photodermatology and melanogenesis, and aspects of cancer related to radio-, chemo-, and photodynamic therapy. Researchers and graduate students in photochemistry, photobiology, photomedicine, radiation chemistry and biology, and cancer therapies will find this book to be of very significant interest.
contains a considerable amount of useful information ... It is well written ... very pleasant and interesting to read ... Students, researchers, and also physicians ... will find competently written introductions to the field, a large amount of interesting information, both on basic research and applications, and a detailed bibliography. * Ester Oliveros and Andre M. Braun, Universitat Karlsruhe, Journal of Photochemistry and Photobiology B: Biology 26 (1994) 103 * 'I recommend this book to both specialists and non-specialists who are interested in knowing more about the molecular basis of biological problems: it is comprehensive, easy to read and competitively priced. The authors should be commended, in my opinion, in having achieved their goal, on the whole, of preparing a text which should be useful to students, research scientists and clinicians who are interested in gaining a deeper appreciation of the molecular
aspects of biological problems.'
Peter O'Neill, Melanoma Research, Vol. 4, 1994