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Excitation-Contraction Coupling and Cardiac Contractile Force : Developments in Cardiovascular Medicine - Donald Bers

Excitation-Contraction Coupling and Cardiac Contractile Force

Developments in Cardiovascular Medicine

Paperback Published: 31st August 1993
ISBN: 9780792324799
Number Of Pages: 265

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The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be useful to students of the cardiovascular system and muscle at all different levels and in different disciplines (such as physiology, biochemistry, pharmacology and pathophysiology). I also hope that it will find use for those studying developmental, comparative and disease processes as well as more integrative phenomenon. I kept several goals in mind in writing this monograph. First, it should be easily readable. Second, I chose to include numerous illustrations and tables to help integrate results from numerous investigators in practical formats and also present key figures from important papers. Thus, this monograph may serve as a resource of information for people working in the areas described herein. Third, the presentation is a very personal one, and I have necessarily drawn extensively on my personal experience in this field over the past 15 years. This, I think, helps maintain a certain continuity of thought from chapter to chapter. Fourth, I have made serious attempts to make each chapter "up to date", despite the breadth of topics covered. I have also tried to be equitable in choosing references while not intending to be comprehensive or exhaustive. Neither of these aims can be perfectly matched, and I apologize to the many investigators whose papers I have not cited, but should have.

The publishers have provided an attractive layout, high quality illustrations, and a good index. Dr. Bers' authoritative review of cardiac excitation-contraction coupling, which represents a lucid and valuable review of this important subject, is highly recommended to the readers of this book.
Developments in Cardiovascular Medicine
'....a remarkably approachable and informative volume, clearly superior to others in this field. Active researchers should buy this book for themselves and their students.' Pharmacological Science 13 1992

Major cellular structures involved in E-C couplingp. 1
Myofilaments: The end effector of E-C Couplingp. 19
Sources and sinks of activator calciump. 39
Cardiac action potentials and ion channelsp. 63
Ca influx via sarcolemmal Ca channelsp. 101
Na/Ca exchange and the sarcolemmal Ca-pumpp. 133
Sarcoplasmic reticulum Ca uptake, content and releasep. 161
Excitation-contraction couplingp. 203
Control of cardiac contraction by SR and sarcolemmal Ca fluxesp. 245
Cardiac inotropy and Ca mismanagementp. 273
Referencesp. 333
Indexp. 407
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792324799
ISBN-10: 079232479X
Series: Developments in Cardiovascular Medicine
Audience: General
Format: Paperback
Language: English
Number Of Pages: 265
Published: 31st August 1993
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 1.52
Weight (kg): 0.41
Edition Type: New edition