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Eukaryotic DNA Damage Surveillance and Repair : Molecular Biology Intelligence Unit - Keith William Caldecott

Eukaryotic DNA Damage Surveillance and Repair

Molecular Biology Intelligence Unit

Hardcover Published: 31st May 2004
ISBN: 9780306479878
Number Of Pages: 161

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Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell cycle control. The work reviews current understanding of how different types of DNA damage are detected and focuses on how these surveillance mechanisms are coupled to processes of DNA repair, cell cycle control, and apoptosis.
The title will be of interest to undergraduate/postgraduate students and academics alike.

Prefacep. vii
DNA Damage Surveillance in Saccharomyces cerevisiaep. 1
Introductionp. 1
Sensing DNA Damage: A Complex Problemp. 4
From Checkpoint Genes to Protein Complexesp. 6
The Rad24 Epistasis Group: RFC-Like and PCNA-Like Complexesp. 7
Mec1/Ddc2: Signal Transduction and Morep. 10
The Mre11 Complex: DSBs and Checkpoint Signallingp. 12
The S Phase Checkpointp. 15
Checkpoints and Genome Surveillancep. 16
Focal Recruitment of Checkpoint and Repair Complexes to Damage Sitesp. 17
The Chromatin Connectionp. 18
Concluding Remarksp. 20
Mammalian Base Excision Repairp. 27
Abstractp. 27
Introductionp. 27
Base Excision Repair Proteinsp. 28
Coordination of Base Excision Repairp. 36
Detection and Repair of DNA Single-Strand Breaksp. 49
Abstractp. 49
The Origin and Structure of DNA Single-Strand Breaksp. 49
The Threat of Single-Strand Breaks to Genetic Stability and Cell Deathp. 50
Polypeptides Involved in DNA Single-Strand Break Repairp. 50
PARP-1, XRCC1 and the Detection of SSBsp. 50
AP Endonuclease-1 (APE1)p. 53
Polynucleotide Kinase (PNK)p. 54
DNA Polymerase-[beta] (Pol[beta])p. 54
DNA Ligase IIIp. 55
SSBR Protein Complexes; Pre-Formed or Assembled at Breaks?p. 56
SSBR Pathways and the Cell Cyclep. 57
The Detection and Repair of Nucleotide Damage and Coupling to Major Cellular Regulatory Processes in Mammalian Cellsp. 63
Abstractp. 63
Introductionp. 63
Types of Damage Repaired by NERp. 66
Recognition of Damage in Nontranscribing Regions of the Genomep. 67
Recognition of Damage in Transcriptionally Active Regions of the Genomep. 68
The Core Excision Process Common to GGR and TCRp. 70
Ubiquitination and Proteolysis in DNA Repairp. 73
Inducible Responses to UV Irradiationp. 74
Kinase Activation and Cellular Response to UV Damagep. 75
Replication of Damaged DNAp. 76
Differentiation and Tissue-Specific Expression of DNA Repair Genesp. 78
Polymorphisms in DNA Repair Genesp. 78
Mammalian DNA Mismatch Repairp. 90
Abstractp. 90
What Is DNA Mismatch Repairp. 90
The Mismatch Repair Mechanismp. 91
The Mismatch Repair Proteinsp. 93
The MutS Homolog Proteinsp. 96
Proteins That Interact with the MuL and MutS Homologuesp. 98
Apoptosis and Drug Resistancep. 101
MMR and Apoptotic Pathwaysp. 102
Conclusionsp. 103
Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cellsp. 107
Abstractp. 107
Replication-Independent Double-Strand Breaks (DSBs)p. 108
Replication Associated DSBs (One-Sided Breaks)p. 121
The Mechanism of DNA Non-Homologous End-Joining: Lessons Learned from Biophysical, Biochemical and Cellular Studiesp. 146
Abstractp. 146
Introductionp. 146
Nature of the DNA Ends to Be Rejoinedp. 147
Structure and Biochemical Analysis of the Core NHEJ Proteinsp. 148
Additional Proteins Implicated in DNA NHEJp. 150
Further Proteins Interacting with Core NHEJ Componentsp. 151
Model for NHEJ and Potential Additional Interacting Proteinsp. 152
Indexp. 159
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780306479878
ISBN-10: 0306479877
Series: Molecular Biology Intelligence Unit
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 161
Published: 31st May 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.67 x 15.9  x 1.68
Weight (kg): 0.45

Earn 587 Qantas Points
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