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Estrogen Effects in Psychiatric Disorders - Niels Bergemann

Estrogen Effects in Psychiatric Disorders

By: Niels Bergemann (Editor), Anita Riecher-Rossler (Editor)

Hardcover Published: 1st January 2005
ISBN: 9783211404850
Number Of Pages: 291

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The study of the effects of gonadal hormones in the brain focussed mainly on reproductive actions for a long time. Meanwhile, however, it is well known that gonadal hormones, in particular estrogens, also have neuroprotective and psychoprotective properties. They modulate many brain functions such as cognitive functions, pain regulation, motor coordination, and epilepsy, as well as affective and psychotic disorders, to name just a few. In fact, during the past few years we have experienced a major change in our understanding of the endocrinologic aspects of psychiatric disorders. Endocrinologic irregularities in psychiatric patients are no longer viewed as pure epiphenomena but rather discussed as part of the pathomechanism of the disorders. How exactly estrogens affect various disorders is a fascinating and intriguing aspect of this emerging field of non-reproductive brain actions of gonadal hormones. Among the estrogens, especially estradiol appears to play an important and multimodal role in the brain. Which of estradiol's many membrane, intracellular, and genomic actions matters most in psychiatric disorders, remains to be discovered. The aim of this volume is to summarize the role estrogens play in major psychiatric disorders, such as schizophrenia, depression, and dementia, and to provide a state-of-the-art overview of current knowledge, but also of questions that are still open. It is intended to be a resource for clinicians and readers who are interested in contemporary research developments in this field.

Introduction and overview
Estrogens in neuropsychiatric disorders : from physiology to pathophysiologyp. 1
Estrogens and schizophreniap. 31
Gender differences in schizophreniap. 53
Puberty and schizophrenia onsetp. 95
Clinical estrogen trials in patients with schizophreniap. 107
Hypoestrogenism and estrogen replacement therapy in women suffering from schizophreniap. 123
The effect of estrogens on depressionp. 145
Estrogens and other hormones in the treatment of premenstrual syndromesp. 175
Estrogens and perinatal disordersp. 191
Estrogen therapy in perimenopausal affective disordersp. 207
The effects of estrogens on cognition and Alzheimer's dementiap. 223
Effects of hormone therapy on patterns of brain activation during cognitive activity : a review of neuroimaging studiesp. 239
Estrogens in Alzheimer's disease : a clinical and neurobiological perspectivep. 253
Estrogen therapy : interface between gynecology and psychiatryp. 271
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783211404850
ISBN-10: 3211404856
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 291
Published: 1st January 2005
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 24.64 x 17.02  x 1.52
Weight (kg): 0.73

Earn 408 Qantas Points
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