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Epidemiology and Control of Neural Tube Defects : Monographs in Epidemiology and Biostatistics - J. Mark Elwood

Epidemiology and Control of Neural Tube Defects

Monographs in Epidemiology and Biostatistics

Hardcover Published: 31st December 1992
ISBN: 9780192618849
Number Of Pages: 942

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Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in etiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

Industry Reviews

`Elwood, Little and Elwood have produced an excellent and comprehensive account of the state of neural tube defect research up to 1991.' The Lancet

An Historical Perspective
Classification, Anatomy, and Embryology
Ascertainment, Registration, and Assessment of Exposure
Geographical Variation
Ethnic Origin and Migration
Secular Trends
Seasonal Variation
Clustering in Time and Space
Early Fetal Loss
Associations with Multiple Pregnancy
Maternal Age and Reproductive History
Maternal Illness and Drug Use in Pregnancy
Socio-economic Status and Occupation
Risks in Siblings and Other Relatives
Genetic Models
Antenatal Screening and Diagnosis
Ethical and Legal Issues
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780192618849
ISBN-10: 0192618849
Series: Monographs in Epidemiology and Biostatistics
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 942
Published: 31st December 1992
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 23.4 x 15.6  x 5.08
Weight (kg): 1.4