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Environmental Factors, Genes, and the Development of Human Cancers - Deodutta Roy

Environmental Factors, Genes, and the Development of Human Cancers

By: Deodutta Roy (Editor), M. Tevfik Dorak (Editor)

Hardcover Published: 17th September 2010
ISBN: 9781441967510
Number Of Pages: 520

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Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene-environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world's experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.

General Principles
Introductionp. 3
Gene-Environment Interactions, Phenotypic Changes, and Human Healthp. 11
Statistics for Testing Gene-Environment Interactionp. 53
Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancersp. 97
Discovering Gene-Gene and Gene-Environment Causal Interactions Using Bioinformatics Approachesp. 115
Gene Environment Interactions and Vascular Lesionsp. 139
Epigenetic Changes in Cancer: Role of Environmentp. 153
Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibilityp. 397
Environment and Specific Types of Cancer
Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumorsp. 223
Genetic Polymorphisms Predisposing Individuals to Breast Cancer Via Gene-Environment Interactionp. 253
Environment, Genetic Immunology and Childhood Cancerp. 277
Exposure to Environmental Mutagens: APC and Colorectal Carcinogenesisp. 303
Gene-Environmental Interactions and Susceptibility to Liver Cancerp. 331
Genetic Epidemiology of Mismatch Repair Deficiency in Ovarian Cancerp. 367
Case Studies
Betel Nut and Susceptibility to Cancerp. 401
Birth Weight and Cancer Associationsp. 429
Iron Excess and Cancerp. 445
Glossaryp. 477
Indexp. 499
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781441967510
ISBN-10: 1441967516
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 520
Published: 17th September 2010
Country of Publication: US
Dimensions (cm): 23.37 x 15.49  x 3.3
Weight (kg): 0.89