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Endotoxins : Structure, Function and Recognition - Xiaoyuan Wang


Structure, Function and Recognition

By: Xiaoyuan Wang (Editor), Peter J. Quinn (Editor)

Hardcover Published: 12th July 2010
ISBN: 9789048190775
Number Of Pages: 415

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Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death.

This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second-discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases.

The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of YA1 endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

From the reviews:

"The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. ... The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. ... very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities." (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)

Structure and Properties of Endotoxins
Endotoxins: Lipopolysaccharides of Gram-Negative Bacteriap. 3
Purification and Characterization of Lipopolysaccharidesp. 27
Endotoxins: Relationship Between Structure, Function, and Activityp. 53
The Diversity of the Core Oligosaccharide in Lipopolysaccharidesp. 69
Salmonella-Regulated Lipopolysaccharide Modificationsp. 101
The Variation of O Antigens in Gram-Negative Bacteriap. 123
Regulators of TLR4 Signaling by Endotoxinsp. 153
Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition?p. 173
Infection, Treatment and Immunity
Endotoxin Detection-from Limulus Amebocyte Lysate to Recombinant Factor Cp. 187
The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejunip. 209
The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infectionp. 241
Development of Small-Molecule Endotoxin Sequestering Agentsp. 255
Development of an Anti-Endotoxin Vaccine for Sepsisp. 285
Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvantsp. 303
Targeting Endotoxin in the Treatment of Sepsisp. 323
Lipopolysaccharides in Rhizobium-Legume Symbiosesp. 339
Lipopolysaccharides and Plant Innate Immunityp. 387
Indexp. 405
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9789048190775
ISBN-10: 9048190770
Series: Subcellular Biochemistry : Book 53
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 415
Published: 12th July 2010
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.89