| Osmotic Problems of Vertebrates | p. 1 |
| General Introduction | p. 1 |
| Geographical and Ecological Distribution of the Vertebrates (Osmotic Distribution) | p. 1 |
| The Osmotic Anatomy of the Vertebrates | p. 4 |
| Osmotic Exchanges with the Environment | p. 8 |
| Physico-Chemical Gradients with the Environment | p. 8 |
| Size and Surface Area | p. 8 |
| Nature of the Integument | p. 8 |
| Metabolism and Oxygen Consumption | p. 9 |
| Feeding | p. 9 |
| Forces Affecting Exchanges of Water and Solutes | p. 9 |
| Diffusion | p. 9 |
| Facilitated Diffusion | p. 10 |
| Osmosis | p. 10 |
| Evaporation | p. 11 |
| Active Solute Transport | p. 11 |
| Transporter Proteins Involved in Solute and Water Movements Across Cell Membranes | p. 12 |
| Biological Structures Participating in Fluid Exchange | p. 20 |
| The Cell Membrane | p. 20 |
| Capillaries | p. 22 |
| Skin | p. 23 |
| Water Loss from the Tetrapod Respiratory Tract | p. 24 |
| Gills | p. 25 |
| Gut | p. 28 |
| Urinary Bladder | p. 31 |
| Salt Glands | p. 32 |
| Kidney | p. 34 |
| Functions | p. 34 |
| Structure | p. 34 |
| Physiology | p. 36 |
| Regulation | p. 38 |
| Relationships of Nitrogen Metabolism to Osmoregulation | p. 39 |
| Osmoregulation and the Evolution of Vertebrates | p. 41 |
| The Vertebrate Endocrine System | p. 45 |
| Endocrine Function | p. 45 |
| Overview | p. 46 |
| Architecture of Hormones and Receptors | p. 46 |
| Morphology of the Endocrine Glands | p. 48 |
| Synthesis of Hormones | p. 49 |
| Release of Hormones | p. 50 |
| Hormones in the Blood | p. 51 |
| Peripheral Metabolism of Hormones | p. 51 |
| Mechanisms of Hormone Action | p. 52 |
| Osmoregulatory Hormones | p. 57 |
| The Hypothalamus and Pituitary Gland | p. 60 |
| The Renin-Angiotensin System (RAS) | p. 66 |
| Adrenocorticosteroids | p. 68 |
| Adrenaline and Noradrenaline | p. 71 |
| The Natriuretic Peptide Hormones | p. 72 |
| Adrenomedullin | p. 74 |
| Guanylin Peptides | p. 75 |
| The Thyroid Hormones | p. 76 |
| The Urotensins | p. 77 |
| Mechanisms of the Hormonal Regulation of Water and Salt Across Epithelial Membranes | p. 78 |
| Vasopressin and Vasotocin | p. 78 |
| Mineralocorticoid Hormones | p. 81 |
| The Mammals | p. 85 |
| General Introduction | p. 85 |
| Osmoregulation | p. 86 |
| Water Loss | p. 87 |
| Cutaneous | p. 87 |
| Respiratory | p. 88 |
| Renal Water Loss | p. 88 |
| Faecal Water Loss | p. 90 |
| Water Loss Associated with Reproduction | p. 90 |
| Salt Loss | p. 91 |
| The Sweat Glands | p. 91 |
| The Gut | p. 91 |
| The Kidney | p. 93 |
| Accumulation of Water and Salts | p. 94 |
| Effects of Dehydration on the Body Fluids | p. 96 |
| The Monotremes (Egg-Laying Mammals) | p. 97 |
| The Marsupials (Pouched Mammals) | p. 98 |
| The Placental Mammals | p. 105 |
| The Birds | p. 113 |
| Water Loss | p. 116 |
| Evaporative | p. 117 |
| Urinary and Faecal | p. 119 |
| Renal Water Conservation and the Neurohypophysis | p. 120 |
| Conservation and Excretion of Salts | p. 122 |
| Kidneys | p. 123 |
| Nasal Salt Glands | p. 124 |
| Conservation of Water and Salt by the Cloaca and Large Intestine | p. 126 |
| Sources of Water and Salts | p. 128 |
| Food | p. 128 |
| Drinking | p. 128 |
| Reproduction, Migration and Osmoregulation | p. 130 |
| Osmoregulation and Hormones in Free-Living Birds | p. 132 |
| The Reptiles | p. 133 |
| Water Exchanges | p. 137 |
| Skin and Respiratory Tract | p. 137 |
| Urinary and Faecal Water Loss | p. 139 |
| Role of the Kidney | p. 140 |
| Role of the Cloaca-Colon Complex | p. 142 |
| Role of the Urinary Bladder | p. 143 |
| Salt Exchanges | p. 144 |
| Skin | p. 144 |
| Kidney | p. 145 |
| Cloaca and Urinary Bladder | p. 147 |
| Cephalic Salt Glands | p. 148 |
| Accumulation of Water and Salts | p. 151 |
| Reproduction and Osmoregulation | p. 152 |
| The Amphibia | p. 155 |
| Water Exchange | p. 163 |
| Skin | p. 163 |
| In Water | p. 163 |
| In Air | p. 167 |
| The Kidney | p. 168 |
| The Urinary Bladder | p. 171 |
| The Large Intestine (Colon) | p. 172 |
| Salt Exchange | p. 173 |
| Skin | p. 174 |
| The Kidney | p. 177 |
| The Urinary Bladder | p. 178 |
| The Large Intestine (Colon) | p. 180 |
| Nitrogen Metabolism | p. 181 |
| Reproduction | p. 182 |
| Accumulation of Water and Salt | p. 184 |
| The Fishes | p. 187 |
| The Piscine Endocrines | p. 190 |
| Neurohypophysial Hormones | p. 191 |
| Adrenocorticosteroids | p. 191 |
| The Renin-Angiotensin System | p. 192 |
| Natriuretic Peptides | p. 193 |
| Catecholamines | p. 193 |
| Thyroid Hormone | p. 194 |
| Urotensins I and II | p. 194 |
| The Growth Hormone/Prolactin Family | p. 195 |
| Water Exchanges | p. 197 |
| The Skin and Gills | p. 198 |
| The Gut | p. 199 |
| The Kidney | p. 202 |
| Salt Exchanges | p. 206 |
| The Skin and Gills | p. 207 |
| The Kidney | p. 217 |
| The Urinary Bladder | p. 218 |
| The Gut | p. 219 |
| Nitrogen Metabolism and Osmoregulation | p. 220 |
| Osmoregulation and the Endocrines of Sharks and Rays | p. 221 |
| The Hagfish | p. 228 |
| References | p. 233 |
| Index | p. 285 |
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