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Encyclopedia of Mass Spectrometry Vol 3 : Volume 3: Biological Applications Part B - M.L. Gross

Encyclopedia of Mass Spectrometry Vol 3

Volume 3: Biological Applications Part B

Hardcover Published: 18th October 2005
ISBN: 9780080438030
Number Of Pages: 580

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Volume 3 looks at classes of biomolecules including carbohydrates, nucleic acids, and lipids. In addition, special areas of application are included, such as pharmaceuticals, natural products, isotope ratio methods for biomolecules analysis, and clinical applications. The articles are arranged under general headings for continuity and ease of access, although several of these are of interest across the various disciplines. The articles are intended to teach and therefore strive to cover basics and sufficient additional detail to bring the reader up-to-date on a given subject. Some advanced topics are also covered, either in a special section of articles or in additional reading citations.
* Covers the major classes of biomolecules including carbohydrates, nucleic acids, and lipids
* Includes special areas of application, such as pharmaceuticals, natural products, isotope ratio methods for biomolecules analysis, and clinical applications
* Written for students entering the field of mass spectrometry

Forewordp. ix
Preface to Volume 3p. xiii
Nucleic Acids
DNA and RNA Sequence Analysisp. 1
RNA Mappingp. 10
Base Analysisp. 14
Enzymatic Digestion of Nucleic Acidsp. 18
Desorption Ionization of Nucleosides and Nucleotidesp. 22
Analysis of DNA Single Nucleotide Polymorphismsp. 39
DNA-Ligand Complexesp. 51
Analysis of DNA Adductsp. 61
High-Throughput Genotyping of Short Tandem Repeat DNA Markersp. 85
Modified Nucleosides in RNA and Human Urinep. 103
Characterization of Noncovalent Complexes of Nucleic Acids and Proteins by Electrospray Ionizationp. 114
Saccharides
GC-MS of Derivatized Carbohydratesp. 129
LC-MS of Carbohydrates from Glycoproteinsp. 144
MALDI MS of Carbohydratesp. 148
Digestion of Glycoprotein Carbohydrates for Glycosylation Analysisp. 172
Structural Elucidation of O-linked Oligosaccharides by Homologous Oligosaccharide Structural Interpretationp. 178
Pharmacology/Toxicology
GC-MS of Drugs and Metabolitesp. 193
LC-MS of Drugs and Metabolitesp. 206
Natural Productsp. 212
LC-MS in Drug Disposition and Metabolismp. 233
Combinatorial Library Screeningp. 274
Oxidative Stress in Cancer and Toxicologyp. 283
Accelerator Mass Spectrometry in Biologyp. 307
Natural Products
Natural Products from Plantsp. 317
Rapid Characterization of Intact Microorganismsp. 322
Nutrition: Applications to Olive Oil, Wine, and Foodp. 327
Isotope Ratio
Quantitative Analysis of Biological Samplesp. 341
Stable Isotopes to Measure In Vivo Metabolism and Kineticsp. 347
Measurement of In Vivo Glucose Metabolism Using Stable Isotope Labelsp. 356
Amino Acid Metabolism and Kineticsp. 367
DNA Synthesis Rates Measured Using Stable Isotopesp. 378
Stable Isotope Breath Testsp. 381
Isotope Ratio in Biology Using CRIMSp. 387
Lipids
Free Fatty Acids and Triacylglycerolsp. 397
Phospholipids by Electrospray Mass Spectrometryp. 414
Analysis of Sphingomyelinsp. 430
Steroid Analysisp. 447
Analysis of Sulfatidesp. 473
Prostaglandins and Metabolitesp. 492
Leukotriene and Lipoxygenase Products by Electrospray Mass Spectrometryp. 502
Isoprostanes and Related Products of Lipid Peroxidation: Characterization and Quantificationp. 517
Clinical Applications
Metabolite Profiling in Urine and Blood for the Diagnosis of Metabolic Disordersp. 527
Serum and Plasma Profilingp. 533
Clinical Applications: Hemoglobin Variantsp. 540
List of Contributorsp. 547
Subject Indexp. 553
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780080438030
ISBN-10: 0080438032
Series: The Encyclopedia of Mass Spectrometry, Ten-Volume Set : Book 3
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 580
Published: 18th October 2005
Country of Publication: GB
Dimensions (cm): 25.71 x 19.25  x 3.86
Weight (kg): 2.03
Edition Number: 3

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