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Emerging Neurological Infections : Neurological Disease and Therapy - Richard T. Johnson

Emerging Neurological Infections

Neurological Disease and Therapy

By: Richard T. Johnson (Editor), Christopher Power (Editor)

Hardcover Published: 4th April 2005
ISBN: 9780824754235
Number Of Pages: 505

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Offering a clear and authoritative overview of recent developments in microbiology and neuroscience, this reference describes factors contributing to the emergence and resurgence of neurological infections--studying both new and drug-resistant pathogens, as well as long-term prevention and control strategies for these diseases.

"a very good overview of these important topicsrecommend[ed] to clinicians, public health professionals, and basic scientists who have an interest in neurovirulence."

Forewordp. xi
Prefacep. xiii
Acknowledgmentsp. xvii
Contributorsp. xix
Microbial Evolution and Emerging Diseasesp. 1
Introduction: A Highly Diverse and Dynamic Microbial Worldp. 1
The Evolution of Microbial Pathogensp. 4
The Emergence and Reemergence of Infectious Diseasesp. 19
Concluding Remarksp. 24
Ecological Disturbances and Emerging Infections: Travel, Dams, Shipment of Goods, and Vectorsp. 35
Introductionp. 35
Travel and Tradep. 36
Changes in Land Usep. 48
Summary and Perspectives For the Futurep. 51
Nipah Encephalitisp. 59
Introductionp. 59
Epidemiologyp. 60
Virologyp. 61
Acute Clinical Manifestationsp. 61
Laboratory Investigation Findingsp. 63
Radiologic Findingsp. 64
Pathology and Pathogenesisp. 65
Treatmentp. 67
Prognosis, Sequelae, and Complicationsp. 67
Infection in Animalsp. 70
The Bat as Reservoir Host: Implications for Future Outbreaksp. 71
Prion Diseases and Dementiap. 77
Introductionp. 77
Prion Proteinp. 78
Doppel, the Prion-Like Proteinp. 79
Clinical and Pathologic Subtypes of PrDp. 80
Creutzfeldt-Jakob Diseasep. 82
Gerstmann-Straussler-Scheinker Syndromep. 93
Fatal Insomniap. 95
The Polymorphic Codon 129p. 97
Acquired PrDp. 98
Differential Diagnosisp. 101
Therapy for PrDp. 102
Arenaviral Hemorrhagic Fevers: Argentine Hemorrhagic Fever and Lassa Feverp. 115
Introductionp. 115
The Virusesp. 115
Epidemiology and Ecologyp. 119
Factors in the Emergence of Arenaviral Hemorrhagic Feversp. 123
Clinical Descriptionp. 124
Clinical Laboratory Studiesp. 128
Other Complementary Examinationsp. 130
Differential Diagnosisp. 130
Etiologic Diagnosisp. 130
Pathology and Pathophysiologyp. 131
Treatmentp. 134
Biosafety Measuresp. 135
Prevention and Controlp. 135
Cerebral Malariap. 145
Introductionp. 145
Epidemiology and Risk Factors for Severe Diseasep. 146
Clinical Featuresp. 149
Pathophysiologyp. 156
Treatmentp. 169
Conclusionp. 174
Rabiesp. 189
Introductionp. 189
Rabies in the United Statesp. 190
Rabies in Europep. 195
Rabies in Australiap. 196
Rabies in Developing Countriesp. 196
Host Switching from Bats to Terrestrial Mammalsp. 198
Non-fatal Outcome of Rabies Virus Infectionsp. 199
Summaryp. 201
Lyme Diseasep. 207
Introductionp. 207
Epidemiologyp. 208
Organismp. 209
Diagnosisp. 222
Summaryp. 229
Flaviviridaep. 239
Introductionp. 239
West Nile Virusp. 240
Japanese Encephalitisp. 247
Neurocysticercosisp. 261
Life Cycle of Taenia soliump. 262
Natural History of Neurocysticercosisp. 264
The Problem of Human African Trypanosomiasisp. 289
The Nature and Scale of the Problemp. 289
Neurological Featuresp. 291
CNS Pathology and Neuropathogenesis of HATp. 296
Control and Treatment of HATp. 299
Enterovirus 71 Encephalitisp. 307
Introductionp. 307
Epidemiologyp. 308
Neurologic Complications and MR Imaging Correlatesp. 309
Associated Complications: Acute Cardiopulmonary Dysfunctionp. 316
Cytokine Levels and the Clinical Severity of EV71 Brainstem Encephalitisp. 318
Autopsy Findingsp. 318
Pathogenesis of Acute Fatality with EV71 Brainstem Encephalitis and Pulmonary Edemap. 319
Neurovirulent Strains vs. Host Susceptibilityp. 319
Potential Treatment and Preventionp. 322
Future Prespectivesp. 323
Guillain-Barre Syndrome and Campylobacter Infectionp. 327
Introductionp. 327
Clinical Features of GBS and Its Variantsp. 328
Pathologyp. 330
Pathogenesisp. 331
Unresolved Issuesp. 347
Reconstruction of Pathogenesisp. 347
Commentp. 348
Latent and Activated Brain Flora: Human Herpesviruses, Endogenous Retroviruses, Coronaviruses, and Chlamydia and Their Role in Neurological Diseasep. 363
Introductionp. 363
Overview of Latent Infectious Agents Associated with Neurological Diseasep. 364
HHV-6 Epidemiology, Roseola, and Association with Immunocompromised Patientsp. 364
HHV-6 Association with Neurological Diseasep. 365
Chlamydia pneumoniaep. 370
Human Coronavirusesp. 373
Human Endogenous Retrovirusesp. 376
Conclusion: How Can Different Latent Infectious Agents Cause a Common Neurological Outcome? A Potential Role for Toll-Like Receptorsp. 379
Herpes Simplex Virus Drug Resistance-HSV Thymidine Kinase Mutantsp. 397
Introductionp. 397
HSV TK Mutantsp. 400
HSV Latency and Reactivationp. 403
The Role of HSV TK in Latency and Reactivationp. 404
The Role of HSV TK Mutants in Human Diseasep. 407
HSV TK and the New Biologyp. 410
Drug-Resistant Bacterial Infections: Implications for Neurosurgical and Neurological Patientsp. 415
Introductionp. 415
Definitionsp. 415
Epidemiologyp. 416
Mechanisms of Resistancep. 417
Therapeutic Implications of Antimicrobial Resistancep. 418
Preventionp. 421
Key Pointsp. 422
Summaryp. 422
HIV-Related Neurological Disease in the Era of HAARTp. 427
Conditions Relating to the Brainp. 428
Conditions Affecting the Spinal Cordp. 438
Peripheral Nerve Manifestations of HIVp. 439
Conclusionp. 445
Gauging the Threats: A Conceptual Framework for Prioritizing Research Directed Toward Interventionp. 453
Introductionp. 453
Categories of Emerging Diseasesp. 454
Illustrative Emerging Neurological Diseasesp. 459
Investigation and Intervention: The Overall Picturep. 462
Immediate Responses to New Infections and the Rapid Development of a Vaccine Strategyp. 472
Introductionp. 471
New Neurological Infectionsp. 472
Clinical Approach to the Identification of a New Infectious Disease in an Individual Patientp. 474
Role of the Neuropathologistp. 476
Developing a Case Definition in the Setting of an Outbreak of a New Central Nervous System Infectionp. 477
Treatmentp. 480
Infection Controlp. 482
Coordination of Public Health, State, and Federal Authoritiesp. 483
Education of the Publicp. 483
Management of Outbreaks in Resource-Poor Countriesp. 485
Rapid Development of Protective Vaccine Strategiesp. 485
Models of Rapid Vaccine Developmentp. 486
Reducing Blocks to Rapid Vaccine Developmentp. 488
Conclusionp. 488
Future Perspectivesp. 493
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780824754235
ISBN-10: 0824754239
Series: Neurological Disease and Therapy
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 505
Published: 4th April 2005
Country of Publication: US
Dimensions (cm): 23.72 x 15.34  x 3.3
Weight (kg): 0.84
Edition Number: 1