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Computational Neuroscience in Epilepsy - Ivan Soltesz

Computational Neuroscience in Epilepsy

By: Ivan Soltesz (Editor), Kevin Staley (Editor)


Published: 2nd September 2011
Format: PDF
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Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). The book should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.

* Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures
* Contributors are top experts at the forefront of computational epilepsy research
* Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Complex synaptic dynamics of GABAergic networks of the hippocampus / Gianmaria Maccaferri -- Experimental and theoretical analyses of synchrony in feedforward networks / Alex. D. Reyes -- Modulation of synchrony by interneurons: insights from attentional modulation of responses in the visual cortex / Paul H.E. Tiesinga and Calin I. Buia -- Pt. VI. Interictal to ictal transitions. Celular and network mechanisms of oscillations preceding and perhaps initiating epileptic discharges / Roger D. Traub, Diego Contreras and Miles A. Whittington -- Transition to ictal activity in temporal lobe epilepsy: insights from macroscopic models / F. Wendling and P. Chauvel -- Unified modeling an analysis of primary generalized seizures / P.A. Robinson, M. Breakspear and J.A. Roberts -- A neuronal network model of corticothalamic oscilations: the emergence of epileptiform absence seizures / Piotr Suffczynski, Syiliyan Kalitzin and F.H. Lopes Da Silva --

ISBN: 9780080559537
ISBN-10: 0080559530
Format: PDF
Language: English
Published: 2nd September 2011
Publisher: Elsevier Science