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Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis : Topics in Neuroscience - O.R. Hommes

Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis

Topics in Neuroscience

Hardcover Published: 6th February 2004
ISBN: 9788847001954
Number Of Pages: 199

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There is now evidence that irreversible brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the disĀ­ ease. Mechanisms ofirreversible axonal damage and the role played by the interĀ­ action of glia and the axon are highlighted. In contrast to what was believed for a long time, the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For reasons not understood, this remyelination process fails or does not start, particularly in the chronic stages ofthe disease. These findings emphasize the importance of the "milieu" changes induced by an inflammatory process in limiting remyelination. However, first indications are that part of this inflammatory process may have a neuroprotective effect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the importance of clinical trials in early multiple sclerosis. Early treatment is one of the most important aspects in multiple sclerosis today.

Evidence for an Early Treatment of Multiple Sclerosisp. 1
Inflammation, Demyelination, and Axonal Degeneration: Three Aspects of the Pathogenesis of Multiple Sclerosis Revealed by Campath-1H Treatmentp. 15
Genetic Regulation of Nerve Cell Death/Glial Activation and Protective Effects of Myelin Basic Protein Autoimmune Neurotrophin Production in Mechanically Induced Neurodegenerationp. 27
Neuroprotective Treatment in Primary Progressive Multiple Sclerosis: A Phase I/II Study with Riluzolep. 41
Neuropathology and Disease Progression in Multiple Sclerosisp. 49
Autoimmune Inflammation and Multiple Sclerosisp. 63
Early Treatment of Progression in Multiple Sclerosisp. 67
Imaging for Tissue Characterization in Multiple Sclerosis and Other White Matter Diseasesp. 83
Monounsaturated Fatty Acids and Neuroprotection. The Results of a Study of Cognitive Decline in Old Age. Is There a Case for this Treatment in Multiple Sclerosis?p. 97
Neuroprotection in Acute Ischemic Stroke: Lessons for Early Treatment in Multiple Sclerosisp. 109
Soluble VCAM-1 Release Indicates Inflammatory Blood-Brain Barrier Pathology and Further Modulates Adhesionp. 115
Early Treatment in Multiple Sclerosis with Intravenous Immunoglobulin: Rationale and Study Designp. 119
Serial Magnetic Resonance Imaging in Patients with a First Clinical Episode Suggestive of Multiple Sclerosis: Outline of a Research Protocolp. 129
T1-Hypointense Lesions (T1 Black Holes) in Mild-to-Moderate Disability Relapsing Multiple Sclerosisp. 135
Acute Monosymptomatic Optic Neuritis: Potential Clues to Early Therapy in Multiple Sclerosisp. 141
Antibody Mediated Demyelinationp. 155
Anti-MOG Antibodies as Early Predictors for Conversion to Relapsing-Remitting Disease Course in Patients Suggestive of Multiple Sclerosisp. 163
Sunlight, Vitamin D, and Multiple Sclerosisp. 167
The Yin and Yang of Inflammation in Multiple Sclerosisp. 181
Management of Interferon-[beta]1b (Betaseron) Failures in Multiple Sclerosis with Interferon-[alpha]n3 (Alferon N)p. 191
Subject Indexp. 197
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9788847001954
ISBN-10: 8847001951
Series: Topics in Neuroscience
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 199
Published: 6th February 2004
Publisher: Springer Verlag
Country of Publication: IT
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 1.08