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Dynamics of Proteins and Nucleic Acids - J. Andrew McCammon

Dynamics of Proteins and Nucleic Acids

Paperback

Published: 25th July 1988
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This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

'McCammon and Harvey's account is easily read and at the same time rewarding to those seeking deeper insight. With its comprehensive and well-balanced list of references, and its review of all the main developments, it will be an invaluable companion to those interested in the dynamics of biological macromolecules.' Nature 'This book will undoubtedly serve as a generally good introductory text for expert and non-expert alike.' Times Higher Education Supplement

Preface
Introduction
Structure of proteins, nucleic acids, and their solvent surroundings
Dynamics of proteins, nucleic acids, and their solvent surroundings
Theoretical methods
Short time dynamics
Local structural transitions
Global structural changes
Dynamics of molecular associations
Recent developments and future directions
Appendices
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521356527
ISBN-10: 0521356520
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 248
Published: 25th July 1988
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 22.86 x 15.24  x 1.42
Weight (kg): 0.37