Dupuytren's contracture is a disease responsible for a considerable portion of disabilities within the working population. Although the riddle of how the contracture of the palmar fascia develops is still unsolved, the data on the pathobiochemistry and clinic of Dupuytren's disease achieved in recent years has led to a better understanding of the biochemical and morphological process underlying the deformation and malfunction of the afflicted tissues. Research in Dupuytren's disease now enters the era of molecular medicine, which opens up new experimental means of studying the pathological changes. In particular, this text presents research on the role of specific biological macromolecules influencing the phenotype expression of the palmar fascia cells which are involved in autoimmune reactions. Complementary evaluation of morphological, epidemiological and clinical data contribute essentially to the present understanding of the etiology and pathogenesis of Dupuytren's disease.
Morphology.- Morphology of Dupuytren's Disease.- Interactions Between Proteoglycans and Collagen Fibrils in the Palmar Fascia in Dupuytren's Disease.- Myofibroblasts Are Not Specific to Dupuytren's Disease.- The Significance of Skin Anchoring Fibres in Palmar Fibrosis: Brief Comment.- Pathobiochemistry of Fibrillar Component.- Collagen Changes in Dupuytren's Disease.- Connective Tissue Autoantibodies in Dupuytren's Disease: Associations with HLA DR3.- Collagen Production by Cultured Dupuytren's Fibroblasts.- Proteoglycans and Glycosaminoglycans.- Proteoglycans in Biopsies of Dupuytren's Contracture.- Glycosaminoglycan Distribution Pattern in Dupuytren's Contracture Biopsies.- Biochemical Parameters for the Diagnosis of Dupuytren's Disease.- Pathobiochemistry of Cells in Dupuytren's Contracture.- Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren's Contracture.- Fibroblast Gel Culture: A Model for Biochemical Investigations of Dupuytren's Contracture.- Reactivity of Cells in Nodules of Dupuytren's Contracture with Monoclonal Antibodies Recognizing Leukocyte Antigens and von Willebrand's Factor.- Demonstration of Myofibroblasts Using a Novel Murine Monoclonal Antibody, 3C2G10.7 Raised from Proliferating Cells in Dupuytren's Disease.- Reactivity of Nodular Cells in Vitro: A Guide to the Pharmacological Treatment of Dupuytren's Contracture.- Extracellular Matrix Components and Macromolecular Interactions.- Stromal-Epithelial Cell Interactions in the Mechanisms of Hepatocyte Injury, Liver Cell Regeneration and Fibrogenesis.- Proteoglycan - Collagen Fibril Interactions in Tissues.- Changes in the Biomechanical Properties of Diseased Tissue as Pathogenetic Factors in Dupuytren's Contracture.- Fibromatoses.- Localization and Morphology of Different Fibromatoses.- Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren's Disease.- Macrophage Activity, Fibronectin, and SPARC Protein in Experimentally Induced Granuloma.- Modulation of Fibroblastic Cytoskeletal Features During Dupuytren's Disease.- Oxygen Free Radicals and Dupuytren's Disease.- Clinical Findings and Epidemiology of Dupuytren's Disease.- Clinical Findings in Dupuytren's Disease.- Epidemiology of Dupuytren's Disease.- Clinical Management of Dupuytren's Disease.- Limited Fasciectomy.- Fasciotomy and the Open Palm Technique.- Skin Grafting in the Management of Dupuytren's Disease.- Recurrence in Dupuytren's Disease.- Refinements of Plastic Surgery in Relapsing Dupuytren's Disease: Incisions, Flaps, Treatment of Perfusion Disorders, Physiotherapy, and Splinting.- The Complications and Unsatisfactory Results of Treatment for Dupuytren's Disease.- The Continuous Elongation Technique in Dupuytren's Disease.
Number Of Pages: 301
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6
Weight (kg): 0.45