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Drug Metabolism : Towards the Next Millennium - N.J. Gooderham

Drug Metabolism

Towards the Next Millennium

By: N.J. Gooderham (Editor), P. Jenner (Editor), Les Patterson (Editor)

Hardcover Published: 1st January 1998
ISBN: 9789051993783
Number Of Pages: 214

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With its roots in the last century and currently exploiting the technology of today, the science of drug metabolism has made significant contributions to our understanding of chemico-biological interactions. This book reviews past successes and failures within the science and attempts to predict new directions. Each of the chapters of this book deals with an aspect of xenobiotic metabolism which has featured prominently in the development of the discipline. The volume is testimony to the breadth and depth of research into xenobiotic metabolism and covers the chemistry and enzymology of xenobiotic metabolism, enzyme modeling and structure activity relationships, pharmacokinetics, the use of recombinant gene technology, site directed mutagenesis, transgenic and gene knockout models, new analytical techniques including capillary electrophoresis-mass spectrometry, accelerator mass spectrometry, high throughput analysis toxicological assessment, pharmacogenetics, drug development and therapeutics. With new chemical entities constantly emerging and requiring evaluation, the concepts and techniques developed in this book will help focus future lines of investigation and help set priorities in the next millennium.

Molecular Modelling in Drug Metabolism: The Cytochromes P450p. 1
Recombinant DNA Methods in Drug Metabolism and Toxicologyp. 13
Oxidation at Carbon via Cytochrome P450 CYP1B1p. 24
Catalytic Mechanism of FMO-Catalysed N- and S-Oxidationsp. 30
Oxidation of Carbon via Molybdenum Hydroxylasesp. 39
The Role of Amine Oxidases in Xenobiotic Metabolismp. 53
Oxidation and Reduction of Nitrogen via CYP450: Importance of the Reduction of Genotoxic N-Hydroxylated Functional Groupsp. 59
Reductive Metabolism: its Application in Prodrug Activationp. 72
Glucuronidation: Towards the Next Millenniump. 80
Sulfotransferases and the Biology of Sulfationp. 89
Glutathione Conjugationp. 101
Clinical Aspects of Polymorphic Drug Metabolismp. 109
Towards the Next Millennium: Pharmacogeneticsp. 119
Metabolism and Genotoxicity of Food-Derived Heterocyclic Aminesp. 127
High Throughput Drug Metabolismp. 137
The Use of Kinetic and Metabolic Predictions in Drug Developmentp. 144
Mass Spectrometry in Drug Metabolismp. 159
Accelerator Mass Spectrometry - A New Tool for Drug Metabolism Studiesp. 175
Overcoming Sample Loading Limitations of On-Line Capillary Electrophoresis-Mass Spectrometry in the Analysis of Drug Metabolites and Xenobiotic Toxinsp. 188
Enantiospecific Bioanalysis: Techniques and Applicationsp. 196
Author Indexp. 213
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9789051993783
ISBN-10: 9051993781
Series: Biomedical and Health Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 214
Published: 1st January 1998
Publisher: IOS Press
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 1.4
Weight (kg): 0.49
Edition Number: 1