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Drug Discovery Strategies and Methods - Alexandros Makriyannis

Drug Discovery Strategies and Methods

Hardcover Published: 4th November 2003
ISBN: 9780824706913
Number Of Pages: 348

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Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

Prefacep. iii
Contributorsp. ix
Protein Crystallography in Structure-Based Drug Designp. 1
Src Homology-2 Domains and Structure-Based, Small-Molecule Library Approaches to Drug Discoveryp. 23
Three-Dimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin-1 by Heteronuclear NMR Spectroscopyp. 61
Cannabinergics: Old and New Possibilitiesp. 89
Development of PET and SPECT Radioligands for Cannabinoid Receptorsp. 129
Structural and Pharmacological Aspects of Peptidomimeticsp. 147
Linkers and Resins for Solid-Phase Synthesis: 1997-1999p. 175
Allosteric Modulation of G-Protein-Coupled Receptors: Implications for Drug Actionp. 221
Protein Misfolding and Neurodegenerative Disease: Therapeutic Opportunitiesp. 245
Uncoating and Adsorption Inhibitors of Rhinovirus Replicationp. 279
Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infectionp. 309
Indexp. 337
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780824706913
ISBN-10: 0824706919
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 348
Published: 4th November 2003
Publisher: Taylor & Francis Inc
Country of Publication: US
Dimensions (cm): 27.9 x 21.6  x 1.91
Weight (kg): 0.6
Edition Number: 1

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