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Drug Delivery : Engineering Principles for Drug Therapy - W. Mark Saltzman

Drug Delivery

Engineering Principles for Drug Therapy

Hardcover Published: 1st April 2001
ISBN: 9780195085891
Number Of Pages: 384

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Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

"Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."--SciTech Book News"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology "Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."--SciTech Book News"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology "Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."--SciTech Book News "[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology "Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."--SciTech Book News "[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology "Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymericbiomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at Cornell University."--SciTech Book News"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even ascientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in thefield of drug delivery ..."--The Quarterly Review of Biology

Introductory material
Introductionp. 3
Historical perspectivep. 3
The aim and structure of this bookp. 5
Drug administration and drug effectivenessp. 9
The state of the artp. 10
Two views of the futurep. 15
Summaryp. 18
Fundamentals
Diffusion and drug dispersionp. 23
Random walksp. 23
Equations for the diffusive flux (Fick's law)p. 29
Equations of mass conservation (Fick's second law)p. 30
Solutions to the diffusion equation with no solute elimination or generationp. 33
Solutions to the diffusion equation with solute binding and eliminationp. 40
A few applicationsp. 43
Summaryp. 48
Diffusion in biological systemsp. 50
Measurement of diffusion coefficientsp. 50
Diffusion in waterp. 55
Diffusion in polymer solutions and gelsp. 65
Diffusion in the extracellular spacep. 76
Diffusion with binding in tissuesp. 90
Diffusion within cellsp. 94
Diffusion and reactionp. 100
Summaryp. 105
Drug permeation through biological barriersp. 113
Mobility of lipids and proteins in the membranep. 113
Permeation through lipid membranesp. 116
Permeation through porous membranesp. 119
Permeation is enhanced by membrane proteinsp. 125
Permeation through cell layersp. 142
Summaryp. 155
Drug transport by fluid motionp. 159
Blood movement in the circulatory systemp. 160
Interstitial fluid movementp. 165
Fluid movement in the lymphatic circulationp. 170
Fluid movement in the brainp. 171
Summaryp. 173
Pharmacokinetics of drug distributionp. 175
Compartmental modelsp. 176
Physiological modelsp. 183
Patterns of mixing in tissues and organsp. 188
The problem of scalep. 193
Summaryp. 195
Drug delivery systems
Drug modificationp. 199
Enhancing agent solubilityp. 200
Enhancing agent stabilityp. 205
Regulating agent permeabilityp. 216
Drug targeting and drug valencyp. 224
Summaryp. 229
Controlled drug delivery systemsp. 235
Reservoir and transdermal delivery systemsp. 236
Matrix delivery systemsp. 245
Hydrogel delivery systemsp. 259
Degradable delivery systemsp. 263
Particulate delivery systemsp. 271
Responsive delivery systemsp. 273
Summaryp. 275
Case studies in drug deliveryp. 281
Controlled delivery of systemic therapyp. 281
Implants for local drug deliveryp. 289
Topically applied devices for controlled releasep. 304
Postscriptp. 316
Overview of polymeric biomaterials
Non-degradable polymersp. 320
Silicone elastomersp. 320
Poly[ethylene-co-(vinyl acetate)]p. 323
Polyurethanesp. 325
Other important polymersp. 329
Biodegradable polymersp. 334
Polyestersp. 334
Copolymers of methyl vinyl ether and maleic anhydridep. 338
Poly(ortho esters)p. 339
Polyanhydridesp. 340
Poly(amino acids)p. 341
Phosphorus-containing polymersp. 342
Polycarbonates and poly(iminocarbonates)p. 342
Polydioxanonep. 343
Water-soluble polymersp. 346
Naturally occurring polymersp. 346
Acrylates and acrylamidesp. 348
Poly(ethylene glycol)p. 349
Useful data and nomenclature
Physiological parametersp. 352
Cardiovascular systemp. 353
Clinical chemistryp. 356
Permeation and diffusionp. 358
Protein propertiesp. 361
Mathematical tables and functionsp. 364
Nomenclaturep. 365
Indexp. 369
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780195085891
ISBN-10: 0195085892
Series: Topics in Chemical Engineering
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 384
Published: 1st April 2001
Country of Publication: US
Dimensions (cm): 23.9 x 15.5  x 2.8
Weight (kg): 0.76