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Disease Progression and Carcinogenesis in the Gastrointestinal Tract : Falk Symposium - P. R. Galle

Disease Progression and Carcinogenesis in the Gastrointestinal Tract

Falk Symposium

By: P. R. Galle (Editor), G. Gerken (Editor), W. E. Schmidt (Editor), B. Wiedenmann (Editor)

Hardcover

Published: 30th September 2003
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Development and progression of gastrointestinal disease involves inflammatory, vascular, fibrogenetic and immune reactions accompanied by deregulation of cellular growth and death often resulting in cancer of the organs affected. This book, the proceedings of Falk Symposium 132 on `Disease Progression and Carcinogenesis in the Gastrointestinal Tract', held in Freiburg, Germany, October 9-10, 2002, addresses these various cellular processes in five sections in order to build up a broad pathogenic concept of gastrointestinal disease, purposely going beyond organ-specific research. Each section combines experts in the various fields of molecular medicine together with clinical scientists in order to stimulate interdisciplinary discussion. In addition, clinical chapters focus on new findings in both diagnostics and therapeutics.

List of principal contributorsp. ix
Prefacep. xi
Stem Cells in the GI Tract
Liver stem cellsp. 3
Liver stem cells in pancreasp. 11
Gastric epithelial progenitor cells and the parietal cell-stem cell dialoguep. 31
Gastrointestinal stem cells: centre stage in the origins of colorectal cancer, of gut cell lineages, and stem cell plasticityp. 41
Stem cell therapy: prospects and implications for the future in hepatologyp. 68
Inflammation in the GI Tract
Cellular immune responses and recovery from hepatitis Cp. 79
Models of cytokine-induced hepatic failurep. 86
Helicobacter pylori and gastric carcinogenesisp. 100
Immunopathogenesis of inflammatory bowel diseasesp. 109
Clinical outlook: immune therapy of inflammatory bowel diseasesp. 117
Cell-Cycle Regulation and Apoptosis in the GI Tract
Molecular mechanisms of liver regeneration: cytokine pathways and their interaction with growth factor signallingp. 135
Regulation of gastric apoptosis and proliferationp. 140
Defective apoptosis in colonic diseasep. 149
Fas inhibition as therapy for preventing fibrogenesis in cholestatic liver diseasesp. 161
Fibrogenesis in the GI Tract
Hepatic fibrogenesisp. 169
Mouse models of liver fibrogenesisp. 179
Carcinogenesis, Prevention and Treatment
Hepatocarcinogenesis and the development of the birth/death imbalance of liver cellsp. 189
Clinical perspectives in the treatment of gastric cancerp. 196
Experimental treatment of pancreatic cancerp. 205
Basement membrane laminins in normal and pathological intestinep. 223
COX-2 inhibitors can prevent colorectal cancer: from observations to expectationsp. 240
Indexp. 247
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780792387855
ISBN-10: 0792387856
Series: Falk Symposium : Book 132
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 260
Published: 30th September 2003
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.25