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Diet and Cancer : Markers, Prevention, and Treatment - Maryce M. Jacobs

Diet and Cancer

Markers, Prevention, and Treatment

By: Maryce M. Jacobs (Editor)

Hardcover Published: 31st May 1994
ISBN: 9780306447235
Number Of Pages: 256

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The American Institute for Cancer Research (AICR) sponsored its third annual confer- ence on nutrition and cancer. The theme was "Diet and Cancer: Markers, Prevention, and Treatment. " The conference was held October 29-30, 1992 at the Ritz Carlton Hotel in McLean, Virginia. This proceedings contains chapters from the platform presentations and abstracts from the poster presentations. Several chapters address each of four session topics: Retinoids as Differentiation Agents in Cancer Therapy, Biological Markers of Cancer Risk, Chemoprevention of Cancer by Non-Nutrients in Foods, and Nutritional Problems and Support in the Treatment of Cancer. The first three chapters discuss in detail different mechanisms by which retinoids influence differentiation and provide evidence to support their use in cancer therapy. In vivo and in vitro studies show the effects of retinoic acid (RA) on tumorigenicity and cellu- lar/molecular events. A synopsis of data showing the involvement of the retinoblastoma (RB) gene in HL-60 cell differentiation induced by RA and 1,2S-dihydroxy vitamin D3 (VD) is presented. In SCID (severe combined immunodeficiency) mice injected with HL-60 3 human leukemia cells and gavaged daily with RA, the number of tumor sites and number of mice with tumors are reduced. All trans-RA induces myeloid differentiation in HL-60 cells. Similarly, VD3 induces HL-60 monocytic differentiation. In both cases an early down regulation of retinoblastoma (RB) gene expression precedes the differentiation.

Vitamin-Regulated Retinoblastoma Tumor Suppressor Gene Expression in Leukemic Cellsp. 1
Retinoic Acid Suppresses Human Papillomavirus Type 16 (HPV16)-Mediated Transformation of Human Keratinocytes and Inhibits the Expression of the HPV16 Oncogenesp. 19
Interactions Between Retinoic Acid and Protein Kinase C in Induction of Melanoma Differentiationp. 37
Racial and Ethnic Issues in Diet and Cancer Epidemiologyp. 59
Dietary Modulation of Oxidative DNA Damagep. 71
Carbohydrate Tumor Marker: Basis for a Simple Test for Colorectal Cancerp. 85
Chemical and Mutagenic Specificities of Polycyclic Aromatic Hydrocarbon Carcinogensp. 101
Inhibition of Tumorigenesis by Chemicals from Garlic and Teap. 113
Cancer Chemoprevention by Green Tea Componentsp. 123
Potential Role of Dietary Isoflavones in the Prevention of Cancerp. 135
Carcinogen-DNA and Protein Adducts as Intermediate Biomarkers for Human Chemoprotection Trialsp. 149
Cytokines, Iron Homeostasis, and Cancerp. 161
Evidence for Nutrient Modulation of Tumor Phenotype: Impact of Tyrosine and Phenylalanine Restrictionp. 171
Possible Role of Neuropeptide Y in Experimental Cancer Anorexiap. 185
Metabolic Alterations and Lactate Overproduction in Insulin Resistant Statesp. 203
Poster Abstractsp. 211
Contributorsp. 249
Indexp. 253
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306447235
ISBN-10: 0306447231
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 256
Published: 31st May 1994
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 1.91
Weight (kg): 1.69