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Diastolic Relaxation of the Heart : The Biology of Diastole in Health and Disease :  The Biology of Diastole in Health and Disease - Beverly H. Lorell

Diastolic Relaxation of the Heart : The Biology of Diastole in Health and Disease

The Biology of Diastole in Health and Disease

By: Beverly H. Lorell (Editor), William Grossman (Editor)

Hardcover

Published: 26th August 2010
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Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease. This brand new Second Edition, based on a recent meeting, includes such topics as: molecular biology of relaxation; consequences of altered gene expression; impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); diastolic dysfunction in the diseased human heart. Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function.

Preface
Contributing Authors
Overview: The Molecular Phenotype of Normal and Impaired Relaxationp. 3
Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Programp. 7
Sarcoplasmic Reticulum Gene Expression in Human Heart Failurep. 17
Molecular Aspects of the Control of Myocardial Relaxationp. 25
Molecular Physiology of Ventricular Hypertrophyp. 33
Regulatory Proteins and Diastolic Relaxationp. 43
Intracellular Free Calcium in Hypertrophy and Failurep. 55
A Molecular Biophysical Approach to Contraction and Relaxationp. 65
On the Relations Among ATP Hydrolysis, Cation Accumulation, and Diastolic Dysfunctionp. 73
Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastolep. 79
Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failurep. 91
Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart. Relevance of SR-Ca[superscript 2+]-ATPase Protein Levelsp. 101
Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Modelp. 111
Diastolic Dysfunction During Ischemia: Role of Glycolytic ATP Generationp. 125
Does Calcium Overload Adequately Explain Diastolic Dysfunction during Metabolic Inhibition?p. 135
Mechanisms of Relaxation: Perspectives from Studies in Single Cardiac Cellsp. 149
Modulation of Diastolic Dysfunction in the Intact Heartp. 167
Altered Load: An Important Component of Impaired Diastolic Function in Hypertension and Heart Failurep. 177
Endothelial-Ventricular Interaction in Normal and Diseased Heartsp. 187
Diastolic Dysfunction in Experimental Heart Failurep. 195
Interplay of Hypertrophy and Myocardial Ischemiap. 203
Myocardial Fibrosis: Structural Basis for Diastolic Dysfunctionp. 213
Coronary Venous Pressure and Left Ventricular Diastolic Distensibilityp. 221
Pericardium and Ventricular Interaction: Effects on Diastolic Fillingp. 233
Diastolic Dysfunction in Tachycardia-Induced Heart Failurep. 243
Diastolic Abnormalities in Low-Flow and Pacing Tachycardia-Induced Ischemia in Isolated Rat Hearts - Modification by Calcium Antagonistsp. 265
Diastolic Dysfunction and Myocardial Energeticsp. 277
Diastolic Dysfunction in Chronic Pressure and Volume Overloadp. 283
Sustained Diastolic Dysfunction Following Severe Exercise-Induced Ischemia in Patients with Coronary Diseasep. 289
Exercise Intolerance in Patients with Heart Failure: Role of Diastolic Dysfunctionp. 295
Comparative Effects of Ischemia and Hypoxemia on Left Ventricular Diastolic Function in Humansp. 303
Determinants of Left Ventricular Diastolic Filling: Insights from Echo-Dopplerp. 323
Indexp. 341
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792326113
ISBN-10: 0792326113
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 348
Published: 26th August 2010
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 26.67 x 19.05  x 1.91
Weight (kg): 1.0
Edition Number: 2
Edition Type: Revised