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Design of Enzyme Inhibitors Volume 2 - Merton Sandler

Design of Enzyme Inhibitors Volume 2

By: Merton Sandler (Editor), H. John Smith (Editor)

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A high proportion of drugs currently coming to market exert their action in the body by inhibiting a target enzyme involved in a particular body function or in a bacterium, protozoon, or virus causing an infection. This book extends the previous volume in providing a comprehensive coverage of more recently recognized target enzymes and their known inhibitors and, within this framework of knowledge, demonstrates how the drug designer uses all available information to develop a specific therapeutic agent. Drug design is an interdisciplinary art; this text illustrates the pathway followed from the initial design concept and synthesis of an inhibitor, through its in vitro and in vivo assessments, to clinical trial -- a process involving chemists, biochemists, pharmacologists, and clinicians.

Preface 1: Enzyme inhibitors as drugs: from design to the clinic 2: Computer-aided molecular design of enzyme inhibitors 3: Protein serine - threonine kinases 4: Inhibitors of protein tyrosine kinases 5: Inhibitors of non-protein kinases 6: Enzyme targets as an approach to therapy for HIV infections 7: Inhibitors of viral DNA Polymerase 8: Fungal enzyme targets 9: Steroidogenesis pathway enzymes 10: HMG-Co A reductase inhibitors 11: DNA topoisomerases 12: Catecholamine - O- methyltrasnferase (COMT) and COMT inhibitors 13: Inhibitors of Phospholipase A 14: Inhibitors of gastric H+, K+ ATPase 15: Inhibitors of mammalian collagenases 16: Inhibitors of Aldose Reductase 17: Miscellaneous topics

ISBN: 9780192621344
ISBN-10: 0192621343
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 848
Published: 21st April 1994
Country of Publication: GB
Dimensions (cm): 23.7 x 16.5  x 5.4
Weight (kg): 1.58