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Dendrimers in Medicine and Biotechnology : New Molecular Tools - U. Dr. Boas

Dendrimers in Medicine and Biotechnology

New Molecular Tools

Hardcover Published: 11th May 2006
ISBN: 9780854048526
Number Of Pages: 179

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Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approach with particular emphasis on biological applications, the book discusses the relationship between the dendrimer molecular motif and its biological properties.

A general introduction to the subject of dendrimers, including definitions of terms and symbols, is provided. Subsequent sections discuss topics including dendrimers in biological systems, dendrimers as drug delivery devices, dendrimers in diagnostics and dendrimer drugs. Throughout the book, examples from current research are also provided.

This book will appeal to a wide range of scientists, including non-specialists who require an introduction to dendrimers, as well as those wishing to know more about the applications of dendrimers in the fields of biology and medicine.

Industry Reviews

Overview of the state-of-the-art in a rapidly moving research.....be essential reading for graduates and academics involved in research in the area. * Chemistry and Industry, 6th November 2006 (David Smith) *
"This book is, indeed, a very timely account of various aspects of the chemical and biological properties of dendrimers, which make them such a versatile tool both for fundamental research and applied biochemistry."

"Dendrimers are still in their infancy, but they attract more and more attention of scientists from various disciplines, and this book will be a very helpful tool for those who are already well familiar or only starting to become acquainted with them." -- Natalia Nalivaeva, University of Leeds * The Biochemist Evolution website *

Dendrimers: Design, Synthesis and Chemical Propertiesp. 1
Introductionp. 1
Terms and Nomenclature in Dendrimer Chemistryp. 3
Dendrimer Designp. 7
Dendrimer Synthesisp. 8
Physicochemical Properties of Dendrimersp. 16
Summaryp. 24
Referencesp. 24
Properties of Dendrimers in Biological Systemsp. 28
Significance of Multivalent Binding in Biological Interactionsp. 28
Dendritic Effectp. 29
Carbohydrate Ligandsp. 30
Biocompatibility of Dendrimersp. 32
In Vitro Cytotoxicity of Dendrimersp. 32
In Vivo Cytotoxicity of Dendrimersp. 43
Biopermeability of Dendrimersp. 46
Biodistribution of Dendrimersp. 55
Immunogenicity of Dendrimersp. 57
Summaryp. 57
Referencesp. 59
Dendrimers as Drug Delivery Devicesp. 62
Introductionp. 62
Dendrimer Hostsp. 63
Dendrimer Hosts: Non-Specific Interactions with the Dendrimer Corep. 64
Dendritic Boxes or Topological Trapping of Guestsp. 70
Dendrimer Hosts: Specific Interactions with the Dendrimer Corep. 71
Dendrimer Hosts: Non-Polar Interactions with the Dendrimer Surface Groupp. 72
Dendrimer Hosts: Polar Interactions with the Dendrimer Surface Groupsp. 73
Covalently Bound Drug-Dendrimer Conjugatesp. 76
Self-Immolative Systemsp. 79
Dendrimers as Gene Transfer Reagentsp. 81
Summaryp. 85
Referencesp. 85
Dendrimer Drugsp. 90
Introductionp. 90
Antiviral Dendrimersp. 91
Antibacterial Dendrimersp. 97
Dendrimers in Antitumour Therapyp. 103
Dendrimers in Therapy of Other Diseasesp. 106
Dendrimer-Based Vaccinesp. 107
Dendrimer Interactions with Proteins. Solublilisation of Protein Aggregatesp. 119
Summaryp. 123
Referencesp. 124
Dendrimers in Diagnosticsp. 130
Contrast Agents based on Dendrimersp. 130
Dendrimer-based Contrast Agents for CTp. 131
Dendrimer-based Contrast Agents for MRIp. 132
Dendrimer-based Contrast Agents for Scintigraphyp. 133
Fluorescence Enhanced by Dendrimersp. 133
Dendrimers in Bioassaysp. 135
Dendrimer-Enhanced Signal Generationp. 135
Dendrimers for Amplifying the Covalent Binding Capacity of Solid Phasesp. 139
Microarray Application of Dendrimersp. 141
Fluorophore-Labelled Dendrimers for Visualisation Purposesp. 145
Using Dendrimers to Increase DNA Extraction Yieldsp. 147
Using Dendrimers for direct Detection of Live Bacteriap. 148
Summaryp. 149
Referencesp. 149
Dendrimers as Biomimicsp. 152
Introductionp. 152
Dendrimers as Protein Mimicsp. 153
Dendrimers as Artificial Enzymesp. 161
Dendrimers as Artificial Antigens, Cell Surfaces and Antibodiesp. 167
Summaryp. 170
Referencesp. 171
Subject Indexp. 173
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780854048526
ISBN-10: 0854048529
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 179
Published: 11th May 2006
Country of Publication: GB
Dimensions (cm): 16.05 x 23.95  x 1.65
Weight (kg): 0.45

Earn 405 Qantas Points
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