Degradation of Bioactive Substances

INTRODUCTION. KINETICS OF WHOLE-BODY AND ORGAN DEGRADATION. Introduction. Compartmental and Multicompartmental Models. Non-Compartmental Models. Whole-Body Degradation. Organ and Tissue Degradation. Conclusion. KINETICS OF ELIMINATION FROM THE BLOOD: PRINCIPLES AND PROCEDURES. Introduction. Kinetic Models in General. Regimes of Elimination. The Concept of Clearance. Special Clearance Regimes. Experimental Procedures. Methodology. Conclusion. PEPTIDASES INVOLVED IN THE METABOLISM OF BIOACTIVE PEPTIDES. Introduction. Properties of the Peptidases. How Do Peptidases Act in Concert? Organ, Tissue and Cellular Locations of Cell Surface Peptidases. Membrane Peptidases as Cluster Differentiation (CD) Antigens. Membrane Anchorage, Release and Plasma Activity of Peptidases. Physiological Roles of Membrane Peptidases. Conclusion. RECEPTOR-MEDIATED ENDOCYTOSIS AND DEGRADATION OF POLYPEPTIDE HORMONES, GROWTH FACTORS AND NEUROPEPTIDES. Perspectives. Receptors for Polypeptide Hormones, Growth Factors and Neuropeptides. Receptor-Mediated Endocytosis. Endocytosis and Degradation of Hormones, Growth Factors, Neuropeptides and Plasma Protein. DEGRADATION OF CIRCULATING RENIN AND ANGIOTENSIN. Introduction. Physiology of Renin and Angiotensin II. Metabolism of Circulating Renin. Metabolism of Circulating Angiotensin II. The Renin-Angiotensin System in Disease. Conclusion. PROCESSING AND CLEARANCE OF ATRIAL NATRIURETIC FACTORS (ANF). Introduction. Processing of ANF Prohormone. Clearance of Bioactive ANF. Conclusion. DEGRADATION OF GASTRIC PEPTIDES: METABOLISM OF THE GASTRINS. Introduction. Structure and Synthesis of the Gastrins. Degradation of the Gastrins. Conclusion. DEGRADATION OF CIRCULATING INTESTINAL PEPTIDES: METABOLISM OF SUBSTANCE P AND VASOACTIVE INTESTINAL POLYPEPTIDE. Introduction. Degradation of Substance P. Degradation of VIP. Conclusion. DEGRADATION OF GLUCAGONS. Introduction. Structure and Synthesis of Glucagon and Related Peptides. Degradation of Glucagon. Degradation o