Day's Veterinary Immunology

Cover
Half Title
Title
Copyright
Contents
Preface (First Edition)
Preface (Second Edition)
Preface (Third Edition)
Author Biographies
Praise for Previous Editions
Abbreviations
Key to Symbols
Chapter 1 An Overview of the Immune System: Important Concepts and Principles of Innate and Adaptive Immunity
1.1 Introduction
1.2 History of Immunology
1.3 The Immune System: An Overview
1.4 Principles of Innate Immunity
1.5 Principles of Adaptive Immunity
1.6 The Evolution of the Immune System
Key Points
Chapter 2 Cells and Tissues of the Immune System
2.1 Introduction
2.2 Haematopoiesis and Production of White Blood Cells
2.3 Primary Lymphoid Tissues
2.4 Secondary Lymphoid Tissues
2.5 The Lymphatic System, Lymphocyte Recirculation and Immune Surveillance
Key Points
Chapter 3 Innate Immunity
3.1 Introduction
3.2 Defensive Barriers
3.3 Pattern Recognition Receptors
3.4 Phagocytes and Phagocytosis
3.5 Innate Lymphoid Cells and Natural Killer Cells
3.6 Lymphocytes with Restricted Diversity of Antigen Receptors
3.7 The Interferon Response
3.8 The Inflammatory Response
3.9 The Acute Phase Response
3.10 Systemic Inflammatory Response Syndrome
3.11 The Complement System
Key Points
Chapter 4 Lymphocyte Development
4.1 Introduction
4.2 Antigen Recognition by Lymphocytes
4.3 Development of B Lymphocytes
4.4 T Cell Development and Maturation
Key Points
Chapter 5 The Major Histocompatibility Complex and Antigen Presentation
5.1 Introduction
5.2 The Major Histocompatibility Complex
5.3 The MHC Class I Processing Pathway
5.4 The MHC Class II Processing Pathway
5.5 Antigen Presention by CD1 Molecules to NKT Cells
5.6 Antigen Presenting Cells
5.7 Genetics and Inheritance of the MHC
5.8 MHC Associations with Immune Function and Disease
5.9 MHC and Transplantation/Tissue Graft Rejection
Key Points
Chapter 6 Cytokines, Chemokines and Their Receptors
6.1 Introduction
6.2 Chemokines and Chemokine Receptors
6.3 Cytokines and Cytokine Receptors
Key Points
Chapter 7 The Biology of T Lymphocytes
7.1 Introduction
7.2 The T Cell Receptor and T Cell Activation
7.3 The Role of CD4+ T Lymphocytes
7.4 The Role of CD8+ T Lymphocytes
7.5 Memory T Cells
Key Points
Chapter 8 Antibody Structure and Function
8.1 Introduction
8.2 Antibody Structure
8.3 Antibody Binding to Antigen
8.4 Biological Properties of Antibody
8.5 Immunoglobulin Classes
Key Points
Chapter 9 The Biology of B Lymphocytes
9.1 Introduction
9.2 Antigen Recognition by B Cells
9.3 Activation of B Lymphocytes
9.4 The Immunoglobulin Class Switch
9.5 Kinetics of the Antibody Response
9.6 Monoclonal Antibodies
Key Points
Chapter 10 Immunodiagnostics: Serology, Immunoassays and Measurement of Cell-Mediated Immunity
10.1 Introduction
10.2 Serological Tests and Immunoassays
10.3 Immunophenotyping
10.4 Lymphocyte Stimulation Assays
10.5 Tests of Cytotoxic Function
10.6 Tests of Phagocytic Cell Function
Key Points
Chapter 11 The Immune Response to Infectious Agents
11.1 Introduction
11.2 The Immune Response to Viral Infection
11.3 The Immune Response to Bacterial Infection
11.4 The Immune Response to Helminth Infection
11.5 The Immune Response to Protozoal Infection
11.6 The Immune Response to Fungal Infection
Key Points
Chapter 12 Immune Evasion by Pathogens
12.1 Introduction
12.2 Evading the Innate Immune Response
12.3 Evading the Antibody-Mediated Adaptive Immune Response
12.4 Evading the Cell-Mediated Adaptive Immune Response
12.5 Specific Viral Strategies for Immune Evasion
Key Points
Chapter 13 Vaccination
13.1 Introduction
13.2 Passive Immunization
13.3 Active Immunization
13.4 Vaccine Technologies
13.5 Vaccines for Non-Infectious Diseases
13.6 Vaccine Adjuvants
13.7 Routes of Administering Vaccines
13.8 Basic Principles of Vaccination
13.9 Vaccination Failure
13.10 Adverse Consequences of Vaccination
Key Points
Chapter 14 Immune System Ontogeny and Neonatal Immunology
14.1 Introduction
14.2 Immune System Ontogeny
14.3 Passive Transfer of Maternal Immune Protection
14.4 Neonatal Vaccination
14.5 Failure of Passive Transfer
14.6 Neonatal Isoerythrolysis
14.7 Early Life Immune Development
Key Points
Chapter 15 Immunological Tolerance and Immune Suppression
15.1 Introduction
15.2 Tolerance and Tolerance Mechanisms
15.3 Central Tolerance
15.4 Peripheral Tolerance
15.5 Mucosal Tolerance
15.6 Fetomaternal and Neonatal Tolerance
15.7 Antibody-Mediated Suppression
15.8 The Neuroendocrine-Immunological Loop
Key Points
Chapter 16 Immunodeficiency
16.1 Introduction
16.2 Primary Immunodeficiency
16.3 Secondary Immunodeficiency
Key Points
Chapter 17 Hypersensitivity Reactions
17.1 Introduction
17.2 The Gell and Coombs Classification of Hypersensitivity
17.3 Type I Hypersensitivity
17.4 Type II Hypersensitivity
17.5 Type III Hypersensitivity
17.6 Type IV Hypersensitivity
Key Points
Chapter 18 Hypersensitivity Disorders and Allergic Disease
18.1 Introduction
18.2 Factors Predisposing to Allergic Disease
18.3 Systemic Allergic Reactions
18.4 Allergic Skin Disease
18.5 Respiratory Disease
18.6 Gastrointestinal Disease
18.7 Diagnosis of Allergic Disease
Key Points
Chapter 19 Autoimmunity and Autoimmune Diseases
19.1 Introduction
19.2 The Genetic Basis for Autoimmunity
19.3 Intrinsic/Host Factors in Susceptibility to Autoimmune Disease
19.4 Extrinsic/Environmental Factors in Susceptibility to Autoimmunity
19.5 Autoimmune Diseases Mediated by Autoantibodies
19.6 Autoimmune Diseases Mediated by Autoreactive T Cells
19.7 Diagnostic Tests for Autoimmune Disease
Key Points
Chapter 20 Cancer Immunology and Immune System Neoplasia
20.1 Introduction
20.2 Tumour Antigens
20.3 The Anti-Tumour Immune Response
20.4 Tumour-Promoting Immune Activity
20.5 Immune Evasion by Tumours
20.6 Immunotherapy to Enhance the Anti-Tumour Immune Response
20.7 Tumours of the Immune System
Key Points
Chapter 21 Immunotherapy
21.1 Introduction
21.2 Immunosuppressive Agents
21.3 Janus Kinase Inhibitors
21.4 Intravenous Immunoglobulin Therapy
21.5 Allergen-Specific Immunotherapy
21.6 Monoclonal Antibody Therapy
21.7 Cytokine Therapy
21.8 Immunostimulatory Agents
Key Points
Chapter 22 Case Studies in Clinical Immunology
22.1 Introduction
22.2 The Basis of Immune-Mediated Disease
22.3 How Common Is Immune-Mediated Disease?
22.4 Immunodiagnostic Testing
22.5 Case 1: Canine Immune-Mediated Haemolytic Anaemia
22.6 Case 2: Canine Immune-Mediated Thrombocytopenia
22.7 Case 3: Canine Systemic Lupus Erythematosus
22.8 Case 4: Feline Blood Transfusion
22.9 Case 5: Feline Multiple Myeloma
22.10 Case 6: Equine Purpura Haemorrhagica
22.11 Case 7: Bovine Thymic Lymphoma
22.12 Case 8: Canine Atopic Dermatitis
22.13 Case 9: Equine Severe Combined Immunodeficiency
22.14 Case 10: Canine Lymphocytic Thyroiditis (Hypothyroidism)
22.15 Case 11: Canine Immune-Mediated Polyarthritis
22.16 Case 12: Bovine Allergic Rhinitis
22.17 Case 13: Canine Drug Reaction
22.18 Case 14: Canine Trapped Neutrophil Syndrome
22.19 Case 15: Feline Lymphoid Leukaemia
22.20 Case 16: Equine Neonatal Isoerythrolysis
22.21 Case 17: A Herd Outbreak of Bovine Viral Diarrhoea Virus Infection
Glossary
Index