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Cytokines and Joint Injury : Progress in Inflammation Research - Wim B. van den Berg

Cytokines and Joint Injury

Progress in Inflammation Research

By: Wim B. van den Berg (Editor), Pierre Miossec (Editor)

Hardcover Published: 24th May 2004
ISBN: 9783764370015
Number Of Pages: 296

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The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. SpeĀ­ cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.

The role of tumour necrosis factor in rheumatoid arthritisp. 1
The IL-1 family : the role of IL-1 and IL-18 in inflammationp. 29
Targeted IL-1 inhibitionp. 69
Is IL-6 a therapeutic target?p. 89
The clinical use of anti-cytokine therapy in rheumatic diseasesp. 107
Innate response cytokines in inflammatory synovitis : interleukin-15 and interleukin-18p. 127
IL-17 as a contributor to inflammation and destruction in rheumatoid arthritisp. 147
Cell-cell contact in chronic inflammation : the importance of cytokine regulation in tissue destruction and repairp. 165
The role of proteinases in joint tissue destructionp. 189
Receptor activator of nuclear factor [kappa]B ligand (RANKL) versus osteoprotegerin (OPG) : the yin and yang of joint integrityp. 221
Cytokine regulation of bone destructionp. 269
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764370015
ISBN-10: 3764370017
Series: Progress in Inflammation Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 296
Published: 24th May 2004
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.84