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Cytochrome P450 : Structure, Mechanism, and Biochemistry - Paul R. Ortiz de Montellano

Cytochrome P450

Structure, Mechanism, and Biochemistry

Hardcover Published: 21st December 2004
ISBN: 9780306483240
Number Of Pages: 690

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Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.

Industry Reviews

Praise for the Second Edition: `Professor Paul R. Ortiz de Montellano (known in some databases as 'P.R.O. Demontellano' has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters.'
ISSX: International Society for Study of Xenobiotics (October 1996)
`The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus.'
Science, 271 (March 1996)

Models and mechanisms of cytochrome P450 action
Computational approaches to cytochrome P450 function
Structures of cytochrome P450 enzymes
Electron transfer partners of cytochrome P450
Activation of molecular oxygen by cytochrome P450
Substrate oxidation by cytochrome P450 enzymes
Inhibition of cytochrome P450 enzymes
Induction of cytochrome P450 enzymes
Hormonal regulation of liver cytochrome P450 enzymes
Human cytochrome P450 enzymes
Cytochrome P450 and the metabolism and bioactivation of arachidonic acid and eicosanoids
Cytochrome P450s in plants
The diversity and importance of microbial cytochromes P450
Human and rat liver cytochromes P450 : functional markers, diagnostic inhibitor probes, and parameters frequently used in P450 studies
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306483240
ISBN-10: 0306483246
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 690
Published: 21st December 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 18.42  x 5.08
Weight (kg): 1.45
Edition Number: 3
Edition Type: Revised