+612 9045 4394
$7.95 Delivery per order to Australia and New Zealand
100% Australian owned
Over a hundred thousand in-stock titles ready to ship
Cytochrome P-450 : Structure, Mechanism, and Biochemistry - Paul Ortiz de Monetllano

Cytochrome P-450

Structure, Mechanism, and Biochemistry

Hardcover Published: 1st March 1986
ISBN: 9780306421471
Number Of Pages: 556

Share This Book:


or 4 easy payments of $73.38 with Learn more
Ships in 15 business days

Earn 587 Qantas Points
on this Book

Other Available Editions (Hide)

  • Paperback View Product Published: 30th April 2013
    Ships in 15 business days

Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de- velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.

1. Metalloporphyrin Models for Cytochrome P-450.- 2. Comparison of the Peroxidase Activity of Hemeproteins and Cytochrome P-450.- 3. The Topology of the Mammalian Cytochrome P-450 Active Site.- 4. Cytochrome P-450 Reductase and Cytochrome b5 in Cytochrome P-450 Catalysis.- 5. Cytochrome P-450 Organization and Membrane Interactions.- 6. Comparative Structures of P-450 Cytochromes.- 7. Oxygen Activation and Transfer.- 8. Inhibition of Cytochrome P-450 Enzymes.- 9. Induction of Hepatic P-450 Isozymes: Evidence for Specific Receptors.- 10. Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways.- 11. Cytochrome P-450 Enzymes in Sterol Biosynthesis and Metabolism.- 12. Cytochrome P450cam and Other Bacterial P-450 Enzymes.- 13. The Crystal Structure of Cytochrome P450cam.- Appendix. Rat Hepatic Cytochrome P-450: Comparative Study of Multiple Isozymic Forms.

ISBN: 9780306421471
ISBN-10: 030642147X
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 556
Published: 1st March 1986
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 24.13 x 16.0  x 4.06
Weight (kg): 1.13

Earn 587 Qantas Points
on this Book

This product is categorised by