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Cyclodextrins in Pharmacy : Topics in Inclusion Science - Karl-Heinz Fromming

Cyclodextrins in Pharmacy

Topics in Inclusion Science

Hardcover Published: 30th November 1993
ISBN: 9780792321392
Number Of Pages: 225

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Nearly three thousand papers and patents are dedicated to the actual or potential uses of cyclodextrins in pharmacy and pharmaceutical formulations. This is the first book written for pharmacists and pharmaceutical technologists which not only critically summarizes the enormous amount of literature available, but which can be used as a handbook when looking for solutions to practical problems.
The fundamentals -- chemistry of cyclodextrins and their derivatives -- their physical and chemical properties are condensed to the most relevant items in Chapters 1 and 2. Chapter 3 deals with the adsorption, metabolism and toxicological properties of cyclodextrins. Chapter 4 explains the formulation, structure, composition and advantageous effects of the cyclodextrin inclusion complexes. Chapter 5 describes the methods for preparation and characterization of drug/cyclodextrin complexes. Chapters 6 and 7 are dedicated to the pharmacokinetics, biopharmaceutical and technological aspects of drug/CD complexes. Chapter 8 treats the application and effects of cyclodextrins in various drug formulations. The Appendix comprises a collection of recipes for any type of drug formulation.
This book is aimed at those who use cyclodextrins in drug formulations, to improve the properties of existing drug formulations, or who want to prepare quite new formulations.

Cyclodextrinsp. 1
Chemical structuresp. 1
Properties of the crystalline CDsp. 4
Properties in solutionp. 9
Production of CDsp. 13
Analytical chemistry of CDsp. 15
Cyclodextrin Derivativesp. 19
General aspects of CD derivatizationp. 19
Effects of chemical modification on the properties of CDsp. 20
Methylated CDsp. 25
Hydroxypropyl CDsp. 27
Soluble polymersp. 29
Insoluble polymersp. 31
Pharmacokinetics and Toxicology of Cyclodextrinsp. 33
Enzymic degradation of CDsp. 33
Absorption and metabolism of CDs in mammalsp. 33
Metabolism in humansp. 36
Toxicology of CDsp. 37
Toxicology of CD derivativesp. 42
Cyclodextrin Inclusion Complexesp. 45
Fundamentalsp. 45
Structure of the inclusion complexesp. 46
CD complexes in solutionp. 50
CD complexes in the solid phasep. 71
Primary consequences of the inclusion of a guest into the CD cavityp. 79
Preparation and Characterization of Cyclodextrin Complexesp. 83
Preparation of CD complexesp. 83
Analysis of CD complexesp. 87
Thermoanalytical methodsp. 88
Solid-state spectroscopic methodsp. 94
Morphological and mechanical propertiesp. 97
Wettability and dissolution propertiesp. 98
Other methodsp. 103
Pharmacokinetics and Biopharmaceuticsp. 105
Pharmacokinetics and biopharmaceutical consequences of complexation of drugs with CDsp. 105
Enhancement of the pharmacological effectsp. 115
Reduction of side effectsp. 120
Pharmaceutical-Technological Aspects of Cyclodextrins in Drug Formulationp. 127
Modification of unpleasant taste and smellp. 127
Fixation of aroma-containing substances and volatile drugsp. 129
Conversion of liquid substances into solid formulationsp. 133
Avoidance of drug-drug and/or drug-additive interactionsp. 134
Granulation and tabletting of CD-containing preparationsp. 134
Noncomplexing applications of CDsp. 143
Limiting factors in CD applicationsp. 146
Cyclodextrins in Various Drug Formulationsp. 151
Formulations, applications, forms and administration routesp. 151
Peroral and oral solid preparations (dosage forms): powders, granules, capsules, tabletsp. 152
Liquid peroral preparationsp. 156
Parenteral preparations: injections, infusions, implantsp. 159
Dermal preparationsp. 165
Rectal and vaginal preparations: suppositories, globulip. 172
Liquid ophthalmic and nasal preparationsp. 180
Other formulationsp. 186
Sustained release formulationsp. 188
Appendix: Recipesp. 197
Hard gelatin capsulesp. 197
Granulesp. 197
Tabletsp. 198
Liquid peroral preparationsp. 201
Parenteral preparationsp. 202
Dermal preparationsp. 203
Rectal and vaginal preparationsp. 207
Liquid nasal preparationsp. 208
Liquid ophthalmic preparationsp. 210
Various formulationsp. 211
Sustained release formulationsp. 213
Legal Status of Cyclodextrinsp. 217
Subject Indexp. 219
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792321392
ISBN-10: 0792321391
Series: Topics in Inclusion Science
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 225
Published: 30th November 1993
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.4 x 15.6  x 1.42
Weight (kg): 1.15