In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April,. 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M.
MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C.
I: Fundamental Aspects.- The epidemiology of melanoma.- The molecular biology of carcinogenesis.- Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application.- Cellular and molecular parameters of tumor progression in human malignant melanoma.- Immune responses to human malignant melanoma.- II: Diagnosis and Prognostic Factors..- Clinical diagnosis of cutaneous melanomas.- Patient's and doctor's delay in diagnosing and treating malignant melanoma of the skin.- Histopathology of cutaneous malignant melanoma.- Immunohistopathological aspects of cutaneous melanoma and precursor lesions.- Prognostic factors for cutaneous melanoma.- III: Treatment.- Incidence of recurrence and survival in clinical stage I patients with melanoma after local excision.- Longterm results of randomized trial comparing immediate versus delayed node dissection in stage I melanoma of the limbs.- Local excision and regional perfusion in high-risk stage-I malignant melanoma of the extremities.- The use of chemotherapy in the management of patients with malignant melanoma.- Radiotherapy of malignant melanoma.- IV: Precursor Lesions.- Congenital nevocelular nevi.- Clinical aspects of the dysplastic nevus syndrome.- Histopathological aspects of dysplastic nevi.- Critical remarks on the dysplastic naevus syndrome.- Index of subjects.