+612 9045 4394
 
CHECKOUT
Curvature and Deformation of Nucleic Acids : Recent Advances, New Paradigms - Nancy C. Stellwagen

Curvature and Deformation of Nucleic Acids

Recent Advances, New Paradigms

By: Nancy C. Stellwagen (Editor), Udayan Mohanty (Editor)

Hardcover

Published: 15th June 2004
RRP $323.95
$196.40
39%
OFF
or 4 easy payments of $49.10 with Learn more
This title is not in stock at the Booktopia Warehouse and needs to be ordered from our supplier.
Click here to read more about delivery expectations.

Curvature and Deformation of Nucleic Acids: Recent Advances, New Paradigms presents an up-to-date review on the curvature and deformation of nucleic acids. Chapter 1 sets the various chapters in context, as well as describing several controversial topics. Chapter 2 gives a comprehensive review of the literature on DNA bending and describes the current status of molecular dynamics simulations of DNA and protein-DNA complexes. Chapter 3 describes the structural basis for A-tract DNA helix bending, based on recent NMR structures and other biophysical measurements. Chapter 4 describes the localization of Mg++ ions in the crystal structure of a B-form DNA dodecamer and discusses the relevance of these bound ions to sequence-dependent bending. Chapter 5 discusses the electrostatic energy penalties that result from phosphate crowding in curved DNA oligomers. Chapter 6 presents a quantitative model that predicts the magnitude of the bend caused by asymmetric charge neutralization of DNA phosphate residues. Chapter 7 reviews the structural and dynamic properties of four-way DNA junctions in the presence of metal ions, and it describes the exchange between alternative stacking conformers in solution. Chapter 8 documents the fact that a conserved pseudouridine residue in an RNA duplex containing a precursor messenger branch site makes an important contribution to the structure of the molecule. Chapter 9 describes structural perturbations that are observed in disease-related mutants of human mitochondrial transfer RNAs. Chapter 10 reviews the thermodynamics of the folding and unfolding of DNA oligomers distorted by the binding of small ligands. Chapter 11 describes a method of constructing DNA fragments for cyclization studies that uses single strand gaps as flexible hinges that allow the correct torsional orientation of the helix ends. Chapter 12 reviews a statistical mechanical model that predicts the stability of reconstituted nucleosomes based on sequence-dependent DNA curvature and flexibility.

Preface 1: Nancy C. Stellwagen and Udayan Mohanty: Curvature and Deformation of Nucleic Acids: Overview 2: D.L. Beveridge, Surjit B. Dixit, K. Suzie Byun, Gabriela Barreiro, Kelly M. Thayer, and S. Ponomarev: Molecular Dynamics of DNA and Protein-DNA Complexes: Progress on Sequence Effects, Conformational Stability, Axis Curvature, and Structural Bioinformatics 3: Douglas MacDonald and Ponzy Lu: The Structural Basis for A-Tract DNA Helix Bending 4: Martin Engli and Valentina Tereshko: Lattice-and Sequence-Dependent Binding of Mg2+ in the Crystal Structure of a B-DNA Dodecamer 5: P.R. Hardwidge, Y.-P. Pang, J.M. Zimmerman, M. Vaghefi, R. Hogrefe, and L.J. Maher, III: Phosphate Crowding and DNA Bending 6: A. Spasic, G. Hess, K. Becker, M. Hansen, R. Bleil, and U. Mohanty: Asymmetric Charge Neutralization of DNA 7: David M.J. Lilley: Structural and Dynamic Properties of Four-Way Helical Junctions in DNA Molecules 8: Nancy L. Greenbaum and Meredith Newby Lambert: Role of a Conserved Pseudouridine in Spliceosomal Pre-mRNA Branch Site Conformation 9: Shana O. Kelley, Lisa Wittenhagen, and Marc D. Roy: Structural Perturbations in Disease-Related Human tRNAs 10: Luis A. Marky, Karen Alessi, Ronald Shikiya, Jian-Sen Li, and Barry Gold: Folding of Bent Oligodeoxynucleotide Duplexes: Energetics, Ion Binding, and Hydration 11: Alexander Vologodskii: Measuring Protein-Induced DNA Bending by Cyclization of Short DNA Fragments Containing Single-Stranded Region 12: P. De Santis, M. Savino, A. Scipioni, and C. Anselmi: DNA Sequence-Dependent Curvature and Flexability in Stability and Organization of Nucleosomes Author Index Subject Index

ISBN: 9780841238626
ISBN-10: 0841238626
Series: ACS Symposium Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 261
Published: 15th June 2004
Publisher: Oxford University Press Inc
Country of Publication: US
Dimensions (cm): 23.6 x 15.9  x 1.8
Weight (kg): 0.48