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Current Topics in Innate Immunity : Advances in Experimental Medicine and Biology - John D. Lambris

Current Topics in Innate Immunity

Advances in Experimental Medicine and Biology

By: John D. Lambris (Editor)

Hardcover

Published: 22nd August 2007
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Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that molecules involved in innate immunity exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system.

The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the 4th International Conference on Innate Immunity (June 4 - 9, 2006), in Corfu, Greece to discuss recent advances in this fast evolving field.

This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.

Toll-like receptors, natural killer cells and innate immunityp. 1
In the thick of the fray : NK cells in inflamed tissuesp. 12
Structural insight into natural killer T cell receptor recognition of CD1dp. 20
The journey of toll-like receptors in the cellp. 35
Differential regulation of key signaling molecules in innate immunity and human diseasesp. 49
Systems biology of macrophagesp. 62
The alternative pathway of complement : a pattern recognition systemp. 80
Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathwayp. 93
Viral heparin-binding complement inhibitors - a recurring themep. 105
C3a receptors signaling in mast cellsp. 126
Antimicrobial C3A - biology, biophysics, and evolutionp. 141
C5L2 - an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3A-DESARG)?p. 159
The exosporium of B.cereus contains a binding site for gC1qR/p33 : implication in spore attachment and/or entry*p. 181
Immunity in borreliosis with special emphasis on the role of complementp. 198
Murine CR1/2 targeted antigenized single-chain antibody fragments induce transient low affinity antibodies and negatively influence an ongoing immune responsep. 214
The third complement component as modulator of platelet productionp. 226
In vivo biological responses in the presence or absence of C3p. 240
Complement activation of drusen in primate model (Macaca fascicularis) for age-related macular degenerationp. 251
Exploring the complement interaction network using surface plasmon resonancep. 260
Glycosylation as a target for recognition of influenza viruses by the innate immune systemp. 279
Immune effects of autoantigen-associated RNAp. 293
Induction and evasion of the type I interferon response by cytomegalovirusesp. 309
Pore formers of the immune systemp. 325
Pathogen-specific innate immune responsep. 342
Flagellin signalling in plant immunityp. 358
Ancient origin of the complement system : emerging invertebrate modelsp. 372
Biological roles of lectins in innate immunity : molecular and structural basis for diversity in self/non-self recognitionp. 389
Hydrogen/deuterium exchange mass spectrometry : potential for investigating innate immunity proteinsp. 407
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780387717654
ISBN-10: 038771765X
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 432
Published: 22nd August 2007
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.81