| Contributors | p. ix |
| Contribution of Membrane Mucins to Tumor Progression Through Modulation of Cellular Growth Signaling Pathways | |
| Mucin Structure, Function, and Involvement in Tumor Progression | p. 2 |
| MUC1 Contributions to Tumor Cell Growth Signaling | p. 5 |
| MUC4 Contributions to Tumor Cell Growth Signaling | p. 10 |
| Inhibition of Signaling by Mucins | p. 14 |
| Perspectives | p. 15 |
| References | p. 16 |
| Regulation of the Epithelial Na[superscript +] Channel by Peptidases | |
| Introduction | p. 24 |
| ENaC Regulation by Peptidases: In Vitro and Biochemical Evidence | p. 25 |
| ENaC Regulation by Peptidases: In Vitro Evidence | p. 31 |
| References | p. 41 |
| Advances in Defining Regulators of Cementum Development and Periodontal Regeneration | |
| Introduction | p. 48 |
| Question 1. What Are the Unknowns That Must Be Considered in Order to Replicate the Enamel (Crown) and How Do the Proteins Involved in Crown Development Relate to Root Development? | p. 51 |
| Question 2. What Do We Know About the Cells Required for Periodontal Development and Regeneration? | p. 63 |
| Question 3. What Genes and Associated Proteins Are Important for Root/Periodontal Tissue Formation? | p. 76 |
| Conclusions and Future Directions | p. 101 |
| Acknowledgments | p. 103 |
| References | p. 103 |
| Anabolic Agents and the Bone Morphogenetic Protein Pathway | |
| Introduction | p. 128 |
| Bone Metabolism | p. 131 |
| The BMP Pathway and Bone Anabolic Therapies | p. 135 |
| Conclusions and Future Directions | p. 153 |
| References | p. 154 |
| The Role of Mammalian Circadian Proteins in Normal Physiology and Genotoxic Stress Responses | |
| Introduction | p. 174 |
| Circadian Rhythms and the Organization of the Mammalian Circadian System | p. 175 |
| Molecular Organization of the Circadian Oscillator in Mammals | p. 176 |
| Human Disorders Associated with Altered Function of the Circadian System | p. 185 |
| Pathologies and Developmental Defects in Circadian Mutant Mice | p. 190 |
| Circadian Control of the Organism's Response to Genotoxic Stress | p. 200 |
| Circadian Proteins as Targets for Therapeutic Intervention | p. 207 |
| Acknowledgments | p. 207 |
| References | p. 207 |
| Autophagy and Cell Death | |
| Introduction | p. 218 |
| Description of Programed Cell Death Morphologies | p. 218 |
| Autophagic Cell Death | p. 219 |
| Autophagy and Autophagic Cell Death Regulatory Mechanisms | p. 222 |
| Autophagy-Apoptosis Crosstalks | p. 234 |
| Survival Versus Death Aspects of Autophagy | p. 236 |
| Conclusions | p. 237 |
| Acknowledgments | p. 238 |
| References | p. 238 |
| Index | p. 247 |
| Contents of Previous Volumes | p. 255 |
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