| Structure, Expression, and Regulation of the IGF-I Gene | p. 1 |
| Differential Regulation of IGF-I Leader Exon Transcription | p. 13 |
| Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics | p. 25 |
| Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins | p. 33 |
| Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS | p. 41 |
| Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins | p. 55 |
| Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression | p. 63 |
| Significant Species Differences in Local IGF-I and II Gene Expression | p. 73 |
| Transcriptional Regulation of the Insulin Receptor Gene Promoter | p. 79 |
| The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors | p. 91 |
| Cell Cycle Control by the IGF-I Receptor and Its Ligands | p. 105 |
| The Insulin Receptor Family | p. 113 |
| IRR: A Novel Member of the Insulin Receptor Family | p. 125 |
| Molecular Properties of Insulin/IGF-I Hybrid Receptors | p. 133 |
| Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes | p. 145 |
| Insulin Like Growth Factor I Receptor Signal Transduction to the Nucleus | p. 159 |
| Molecular Cloning of pp120/ ECTO-ATPase, an Endogenous Substrate of the Insulin Receptor Kinase | p. 169 |
| The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression | p. 175 |
| Parental Imprinting of the Genes for IGF-II and Its Receptor | p. 189 |
| Multihormonal Regulation of IGFBP-1 Promoter Activity | p. 205 |
| Insulin-Like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life | p. 215 |
| Rapid Regulation of Insulin-Like Growth Factor Binding Protein-1 Transcription by Insulin In Vitro and In Vivo | p. 227 |
| IGF Binding Protein-3 and the Acid-Labile Subunit: Formation of the Ternary Complex In Vitro and In Vivo | p. 237 |
| Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin Like Growth Factor Binding Proteins | p. 245 |
| Cellular Actions of Insulin-Like Growth Factor Binding Protein-3 | p. 255 |
| Gene Expression of the IGF Binding Proteins During Post-Implantation Embryogenesis of the Mouse: Comparison with the Expression of IGF-I and -II and Their Receptors in Rodent and Human | p. 267 |
| Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression and the Development of Transgenic Mouse Models to Study IGFBP-1 Function | p. 279 |
| Limited Proteolysis of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): A Physiological Mechanism in the Regulation of IGF Bioavailability | p. 293 |
| Effects of Insulin-Like Growth Factor 1 (IGF-I) Administrations on Serum IGF Binding Proteins (IGFBPS) in Patients with Growth Hormone Deficiency | p. 301 |
| Metabolic Effects of rhIGF-I in Normal Human Subjects | p. 311 |
| IGFS and Muscle Differentiation | p. 319 |
| IGF-II in the Pathogenesis of Rhabdomyosarcoma: A Prototype of IGFS Involvement in Human Tumorigenesis | p. 327 |
| The Physiology and Pathophysiology of IGF-I in the Kidney | p. 345 |
| Regulation of IGFBP-4 and -5 Expression in Rat Granulosa Cells | p. 367 |
| Insulin-Like Growth Factor (IGF) Binding Protein-1 is an Antigonadotropin: Evidence That Optimal Follicle-Stimulating Hormone Action in Ovarian Granulosa Cells is Contingent Upon Amplification by Endogenously-Derived IGFs | p. 377 |
| Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in the Zucker Fatty Rat: A Case for Differential Tissue Regulation | p. 387 |
| Characterization of the IGF Regulatory System in Bone | p. 397 |
| Regulation of IGF Activity in Bone | p. 407 |
| Index | p. 415 |
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