Current Directions in Insulin-Like Growth Factor Research

By: Derek LeRoith (Editor), Mohan K. Raizada (Editor)

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Proceedings of the Fourth International Symposium on Insulin, IGFs, and their receptors, held in Woods Hole, Massachusetts, April 1993, under the auspices of the American Diabetes Association. The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Amon

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Structure, Expression, and Regulation of the IGF-I Gene	p. 1
Differential Regulation of IGF-I Leader Exon Transcription	p. 13
Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics	p. 25
Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins	p. 33
Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS	p. 41
Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins	p. 55
Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression	p. 63
Significant Species Differences in Local IGF-I and II Gene Expression	p. 73
Transcriptional Regulation of the Insulin Receptor Gene Promoter	p. 79
The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors	p. 91
Cell Cycle Control by the IGF-I Receptor and Its Ligands	p. 105
The Insulin Receptor Family	p. 113
IRR: A Novel Member of the Insulin Receptor Family	p. 125
Molecular Properties of Insulin/IGF-I Hybrid Receptors	p. 133
Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes	p. 145
Insulin Like Growth Factor I Receptor Signal Transduction to the Nucleus	p. 159
Molecular Cloning of pp120/ ECTO-ATPase, an Endogenous Substrate of the Insulin Receptor Kinase	p. 169
The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression	p. 175
Parental Imprinting of the Genes for IGF-II and Its Receptor	p. 189
Multihormonal Regulation of IGFBP-1 Promoter Activity	p. 205
Insulin-Like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life	p. 215
Rapid Regulation of Insulin-Like Growth Factor Binding Protein-1 Transcription by Insulin In Vitro and In Vivo	p. 227
IGF Binding Protein-3 and the Acid-Labile Subunit: Formation of the Ternary Complex In Vitro and In Vivo	p. 237
Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin Like Growth Factor Binding Proteins	p. 245
Cellular Actions of Insulin-Like Growth Factor Binding Protein-3	p. 255
Gene Expression of the IGF Binding Proteins During Post-Implantation Embryogenesis of the Mouse: Comparison with the Expression of IGF-I and -II and Their Receptors in Rodent and Human	p. 267
Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression and the Development of Transgenic Mouse Models to Study IGFBP-1 Function	p. 279
Limited Proteolysis of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): A Physiological Mechanism in the Regulation of IGF Bioavailability	p. 293
Effects of Insulin-Like Growth Factor 1 (IGF-I) Administrations on Serum IGF Binding Proteins (IGFBPS) in Patients with Growth Hormone Deficiency	p. 301
Metabolic Effects of rhIGF-I in Normal Human Subjects	p. 311
IGFS and Muscle Differentiation	p. 319
IGF-II in the Pathogenesis of Rhabdomyosarcoma: A Prototype of IGFS Involvement in Human Tumorigenesis	p. 327
The Physiology and Pathophysiology of IGF-I in the Kidney	p. 345
Regulation of IGFBP-4 and -5 Expression in Rat Granulosa Cells	p. 367
Insulin-Like Growth Factor (IGF) Binding Protein-1 is an Antigonadotropin: Evidence That Optimal Follicle-Stimulating Hormone Action in Ovarian Granulosa Cells is Contingent Upon Amplification by Endogenously-Derived IGFs	p. 377
Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in the Zucker Fatty Rat: A Case for Differential Tissue Regulation	p. 387
Characterization of the IGF Regulatory System in Bone	p. 397
Regulation of IGF Activity in Bone	p. 407
Index	p. 415
Table of Contents provided by Blackwell. All Rights Reserved.

Current Directions in Insulin-Like Growth Factor Research

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